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dc.contributor.authorRogalska, Aneta
dc.date.accessioned2025-02-27T13:09:00Z
dc.date.available2025-02-27T13:09:00Z
dc.date.issued2025
dc.identifier.urihttp://hdl.handle.net/11089/54820
dc.description.abstractEpithelial ovarian cancer (EOC) remains a leading cause of gynecologic cancer mortality. Despite advances in treatment, metastatic progression and resistance to standard therapies significantly worsen patient outcomes. Epithelial-mesenchymal transition (EMT) is a critical process in metastasis, enabling cancer cells to gain invasive and migratory capabilities, often driven by changing miRNA expression involved in the regulation of pathological processes like drug resistance. Targeted therapies like PARP inhibitors (PARPi) have improved outcomes, particularly in BRCA-mutated and DNA repair-deficient tumors; however, resistance and limited efficacy in advanced stages remain challenges. Recent studies highlight the potential synergy of PARPi with DNA damage response (DDR) inhibitors, such as ATR and CHK1 inhibitors, which disrupt cancer cell survival pathways under stress. This study investigated the combined effects of olaparib with ATR and CHK1 inhibitors (ATRi and CHK1i) on migration, invasion, and EMT-related protein expression and miRNA expression in ovarian cancer cell lines OV-90 and SKOV-3. The results demonstrated enhanced cytotoxicity, inhibition of migration and invasion, and modulation of miRNAs linked to metastasis. These findings suggest that combination therapies targeting DNA repair and cell cycle pathways may offer a novel, more effective approach to managing advanced EOC and reducing metastatic spread.pl_PL
dc.description.sponsorshipNational Science Centre, Poland (project grant number: Sonata Bis 2019/34/E/NZ7/00056).pl_PL
dc.rightsCC0 1.0 uniwersalna*
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/*
dc.subjectDDR inhibitorspl_PL
dc.subjectEMTpl_PL
dc.subjectPARPipl_PL
dc.subjectmiRNApl_PL
dc.subjectovarian cancerpl_PL
dc.titleOlaparib Combined with DDR Inhibitors Effectively Prevents EMT and Affects miRNA Regulation in TP53-Mutated Epithelial Ovarian Cancer Cell Linespl_PL
dc.typeDatasetpl_PL
dc.contributor.authorAffiliationDepartment of Medical Biophysics, Institute of Biophysics, Faculty of Biology and Environmental Protection, University of Lodz, 141/143 Pomorska Street, 90-236, Lodz, Poland.pl_PL
dc.contributor.authorEmailaneta.rogalska@biol.uni.lodz.plpl_PL
dc.disciplinenauki biologicznepl_PL


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