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dc.contributor.authorKowalczyk-Pachel, Danuta
dc.contributor.authorChwatko, Grażyna
dc.contributor.authorIciek, Małgorzata
dc.contributor.authorCzyżyk, Joanna
dc.contributor.authorFilip, Małgorzata
dc.contributor.authorWłodek, Lidia
dc.contributor.authorLorenc-Koci, Elżbieta
dc.descriptionReceived: 28 November 2012 / Revised: 19 April 2013 / Accepted: 6 May 2013 / Published online: 16 May 2013 The Author(s) 2013. This article is published with open access at Springerlink.compl_PL
dc.description.abstractThe aim of the present studies was to evaluate cocaine-induced changes in the concentrations of different redox forms of cysteine (Cys) and homocysteine (Hcy), and products of anaerobic Cys metabolism, i.e., labile, reduced sulfur (LS) in the rat plasma. The above-mentioned parameters were determined after i.p. acute and subchronic cocaine treatment as well as following i.v. cocaine self-administration using the yoked procedure. Additionally, Cys, Hcy, and LS levels were measured during the 10-day extinction training in rats that underwent i.v. cocaine administration. Acute i.p. cocaine treatment increased the total and protein-bound Hcy contents, decreased LS, and did not change the concentrations of Cys fractions in the rat plasma. In turn, subchronic i.p. cocaine administration significantly increased free Hcy and lowered the total and protein-bound Cys concentrations while LS level was unchanged. Cocaine self-administration enhanced the total and protein-bound Hcy levels, decreased LS content, and did not affect the Cys fractions. On the other hand, yoked cocaine infusions did not alter the concentration of Hcy fractions while decreased the total and protein-bound Cys and LS content. This extinction training resulted in the lack of changes in the examined parameters in rats with a history of cocaine self-administration while in the yoked cocaine group an increase in the plasma free Cys fraction and LS was seen. Our results demonstrate for the first time that cocaine does evoke significant changes in homeostasis of thiol amino acids Cys and Hcy, and in some products of anaerobic Cys metabolism, which are dependent on the way of cocaine administration.pl_PL
dc.publisherSpringer Verlagpl_PL
dc.relation.ispartofseriesNeurotox Res;(2013) 24
dc.rightsUznanie autorstwa 3.0 Polska*
dc.subjectYoked procedurepl_PL
dc.titleThe Effects of Cocaine on Different Redox Forms of Cysteine and Homocysteine, and on Labile, Reduced Sulfur in the Rat Plasma Following Active versus Passive Drug Injectionspl_PL
dc.contributor.authorAffiliationD. Kowalczyk-Pachel M. Iciek L. Włodek The Chair of Medical Biochemistry, Jagiellonian University Collegium Medicumpl_PL
dc.contributor.authorAffiliationG. Chwatko Department of Environmental Chemistry, University of Łódźpl_PL
dc.contributor.authorAffiliationM. Filip Department of Toxicology, Faculty of Pharmacy, Jagiellonian University College of Medicinepl_PL
dc.contributor.authorAffiliationJ. Czyżyk, M. Filip, E. Lorenc-Koci Laboratory of Drug Addiction Pharmacology, Institute of Pharmacology, Polish Academy of Sciencespl_PL
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Uznanie autorstwa 3.0 Polska
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