http://hdl.handle.net/11089/14642 2026-04-09T15:32:54Z 2026-04-09T15:32:54Z Szmigiero, Leszek http://hdl.handle.net/11089/15208 2018-02-01T11:20:19Z 1999-01-01T00:00:00Z

Analiza uszkodzeń DNA w komórkach ssaków metodą elucji alkalicznej Szmigiero, Leszek DNA alkaline elution is one of the most prominent methods which are currently in use for investigation of the effects of genotoxic agents. The main advantage of this technique is its high sensitivity as well as versatility that allows one to m easure a variety of DNA lesions. Basic principles of the method and its research applications are reviewed.

1999-01-01T00:00:00Z Watała, Cezary Boncler, Magdalena Różalski, Marcin http://hdl.handle.net/11089/15207 2018-02-01T11:20:07Z 1999-01-01T00:00:00Z

Znaczenie uwarunkowań genetycznych w dysfunkcjach układu hemostazy w cukrzycy - potencjalne czynniki ryzyka powikłań naczyniowych Watała, Cezary; Boncler, Magdalena; Różalski, Marcin The unambiguous determination of etiopathogenetic factors underlying the increased risk of vascular disease in diabetic patients remains to be established. Evidence accumulated hitherto points that such an increased risk might be a constellation of metabolic disorders and genetic background. Thus, the impairments in coagulation and fibrinolysis, which are believed to partly result from metabolic disorders encountered in diabetes, and genetic factors might be compounding in predisposing a diabetic individual to develop the late diabetic sequelae sooner. The role of the latter seems superior with respect to some dysfunctions in haemostasis. Hence, the monitoring of the frequency and distribution of genetic polymorphisms of selected haemostatic proteins might be promising in an attempt to define the reasons of altered haemostatic imbalance in patients with diabetes mellitus. Based on such a knowledge one could discriminate the groups of patients with high risk for the development of vascular disease, in whom pharmacological strategy to attenuate haemostatic impairments would be desirable.

1999-01-01T00:00:00Z Pietrucha, Tadeusz Szemraj, Janusz Chiżyński, Krzysztof http://hdl.handle.net/11089/15206 2018-02-01T11:20:16Z 1999-01-01T00:00:00Z

Genetyczne uwarunkowania funkcjonowania mechanizmu hemostazy w chorobach układu krążenia rola polimorfizmu regionów promotorowych Pietrucha, Tadeusz; Szemraj, Janusz; Chiżyński, Krzysztof In this review the potential role of polymorphism gene promoter regions of beta-chain fibrinogen and plasminogen activator inhibitor type I (PAI-1) in cardiovascular disease is discussed. The thorough discussion covers the potential mechanisms of their effect.

1999-01-01T00:00:00Z Więcławska, Bogusława Watała, Cezary http://hdl.handle.net/11089/15205 2018-02-01T11:20:07Z 1999-01-01T00:00:00Z

Modulacja aktywacji płytek krwi - antagoniści receptora tromboksanu i modulatory receptorów eikozanoidowych Więcławska, Bogusława; Watała, Cezary

1999-01-01T00:00:00Z