http://hdl.handle.net/11089/24297 2026-04-03T18:51:36Z 2026-04-03T18:51:36Z Szczotka, Paulina http://hdl.handle.net/11089/24315 2019-04-02T10:07:31Z 2017-12-29T00:00:00Z

Conditional probability of the daily minimum temperature in certain types of circulation on a seasonal basis in the Zywiec Valley in Southern Poland Szczotka, Paulina Air minimum temperature is very important for the natural environment and human activity. This paper presents certain aspects related to the variability of daily minimum temperature of air in the winter (XII, I, II) in the Zywiec Valley, in relation to the synoptic situation in the valley. The analysis is based on the results of research carried out at one point node (the grid) obtained from the base Carpat Clim database. The node is located at the bottom of the Zywiec Valley in the period 1961-2010. The study was complemented with a comprehensive analysis of local conditions for atmospheric circulation and temporal variability over a 50 years period. For this purpose, the classification of types of atmospheric circulation (Niedźwiedź 1981) was used for the upper Vistula river basin. Extreme temperatures included an average minimum temperature of air exceeding the 90th and 95th percentile. The relationship between the extremes of air temperature and atmospheric circulation types was examined by analyzing the frequency of occurrence of extreme values and their conditional occurrence in each particular type of atmospheric circulation.

2017-12-29T00:00:00Z Grabarek, Beniamin Bednarczyk, Martyna Mazurek, Urszula http://hdl.handle.net/11089/24313 2019-04-02T10:07:58Z 2017-12-29T00:00:00Z

The characterization of tumor necrosis factor alpha (TNF-α), its role in cancerogenesis and cardiovascular system diseases and possibilities of using this cytokine as a molecular marker Grabarek, Beniamin; Bednarczyk, Martyna; Mazurek, Urszula The inflammatory process is directly associated with secretion of cytokines, e.g. tumor necrosis factor alpha (TNF-α). This molecule is one of the 22 proteins which belong to TNF family and is secreted mainly by: macrophages, monocytes, T lymphocyte and mast cells. The biological effects of TNF-α is possible through binding this cytokine to specific receptors - TNFR1 and TNFR2. The large number of reports provides that this cytokine plays extremely important role in cancers and cardiovascular disease - two groups of inflammatory diseases. Unfortunately, these diseases are the main cause of death in spite of advances in medicine and increasing public awareness of prevention. It is believed that better understanding both molecular potential of this cytokine and the impact in cancerogenesis and others inflammatory diseases may cause using TNF-α as a molecular marker in these diseases and will make it possible to observe the effects of anti-inflammatory therapy. It will be able to cause a drop in the incidence of these diseases and better monitoring of them.

2017-12-29T00:00:00Z Piaścik, Magda Zegarlińska, Jolanta Sikorski, Aleksander F. Czogalla, Aleksander http://hdl.handle.net/11089/24314 2019-04-02T10:07:44Z 2017-12-29T00:00:00Z

Optimization of flotation assay conditions for syndapin binding to phosphatidic acid containing liposomes Piaścik, Magda; Zegarlińska, Jolanta; Sikorski, Aleksander F.; Czogalla, Aleksander Flotation is one of the best method for preliminary identification of protein-lipid interactions. In most widely used approach it utilizes large unilamellar vesicles, that are excellent models of freestanding membranes and do not require any additional components, like solid supports or beads that are needed in other methods commonly used for protein-lipid binding studies. Here we present results obtained during our studies on phosphatidic acid - syndapin interactions and discuss some technical aspects of this method underlying how relatively small changes in the conditions can influence the results.

2017-12-29T00:00:00Z