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dc.contributor.authorBalcerczyk, Aneta
dc.contributor.authorBartosz, Grzegorz
dc.contributor.authorDrzewinska, Joanna
dc.contributor.authorPiotrowski, Łukasz
dc.contributor.authorPulaski, Lukasz
dc.contributor.authorStefek, Milan
dc.date.accessioned2016-04-07T11:55:14Z
dc.date.available2016-04-07T11:55:14Z
dc.date.issued2014
dc.identifier.urihttp://hdl.handle.net/11089/17744
dc.description.abstractThe aim of the study was to evaluate the antioxidant action of SMe1EC2, the structural analogue of the hexahydropyridoindole antioxidant stobadine. The antiradical activity of SMe1EC2 was found to be higher when compared to stobadine, as determined both in cell-free model systems of AAPH-induced oxidation of dihydrorhodamine 123 and 2´,7´-dichloro-dihydrofluorescein diacetate, and in the cellular system of stimulated macrophages RAW264.7. Analysis of proliferation of HUVEC and HUVEC-ST cells revealed absence of cytotoxic effect of SMe1EC2 at concentrations below 100 μM. The antioxidant activity of SMe1EC2, superior to the parent drug stobadine, is accounted for by both the higher intrinsic free radical scavenging action and by the better bioavailability of the low-basicity SMe1EC2 relative to the high-basicity stobadine.pl_PL
dc.description.sponsorshipFinancial support by the grants VEGA 2/0067/11 and COST CM1001 action is gratefully acknowledgedpl_PL
dc.language.isoenpl_PL
dc.publisherDe Gruyter Openpl_PL
dc.relation.ispartofseriesInterdisciplinary Toxicology;1
dc.rightsUznanie autorstwa 3.0 Polska*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/pl/*
dc.subjectantioxidantpl_PL
dc.subjecthexahydropyridoindolepl_PL
dc.subjectSMe1EC2pl_PL
dc.subjectstobadinepl_PL
dc.subjectoxidative stresspl_PL
dc.titleAntioxidant action of SMe1EC2, the low-basicity derivative of the pyridoindole stobadine, in cell free chemical models and at cellular levelpl_PL
dc.typeArticlepl_PL
dc.page.number27–32pl_PL
dc.contributor.authorAffiliationUniversity of Lodz, Department of Molecular Biophysicspl_PL
dc.contributor.authorAffiliationUniversity of Rzeszow, Department of Biochemistry and Cell Biologypl_PL
dc.contributor.authorAffiliationCenter of Medical Biology, Laboratory of Transcriptional Regulationpl_PL
dc.contributor.authorAffiliationSlovak Academy of Sciences, Institute of Experimental Pharmacology and Toxicologypl_PL
dc.identifier.eissn1337-9569
dc.referencesCrow JP. (1997). Dichlorodihydrofluorescein and dihydrorhodamine 123 are sensitive indicators of peroxynitrite in vitro: implications for intracellular measurement of reactive nitrogen and oxygen species. Nitric Oxide 1(2): 145-157pl_PL
dc.referencesIschiropoulos H, Gow A, Thom SR, Kooy NW, Royall JA, Crow JP. (1999). Detection of reactive nitrogen species using 2,7-dichlorodihydrofluorescein and dihydrorhodamine 123. Methods Enzymol 301: 367-373pl_PL
dc.referencesGasparova Z, Janega P, Babal P, Snirc V, Stolc S, Mach M, Ujhazy E. (2009). Effect of the new pyridoindole antioxidant SMe1EC2 on functional deficits and oedema formation in rat hippocampus exposed to ischaemia in vitro. Neuro Endocrinol Lett 30: 574-581pl_PL
dc.referencesGasparova Z, Ondrejickova O, Gajdosikova A, Gajdosik A, Snirc V, Stolc S. (2010). Oxidative stress induced by the Fe2+/ascorbic acid system or model ischemia in vitro: Effect of carvedilol and pyridoindole antioxidant SMe1EC2 in young and adult rat brain tissue. Interdiscip Toxicol 3: 122-126pl_PL
dc.referencesGasparova Z, Snirc V, Stolc S. (2011). The new pyridoindole antioxidant SMe1EC2 and its intervention in hypoxia/hypoglycemia-induced impairment of longterm potentiation in rat hippocampus. Interdiscip Toxicol 4: 56-61pl_PL
dc.referencesGasparova Z, Stara V, Stolc, S. (2014). Effect of antioxidants on functional recovery after in vitro-induced ischemia and long-term potentiation recorded in pyramidal layer of the CA1 area of rat hippocampus. Gen Physiol Biophys 33(1): 43-52pl_PL
dc.referencesHorakova L, Stolc S. (1998). Antioxidant and pharmacodynamic effects of pyridoindole stobadine. Gen Pharmacol 30: 627-638pl_PL
dc.referencesJaffe EA, Nachman RL, Becker CG, Minick CR. (1973). Culture of human endothelial cells derived from umbilical veins. J Clin Invest 52: 2745-2756pl_PL
dc.referencesJuranek I, Horakova L, Rackova L, Stefek M. (2010). Antioxidants in treating pathologies involving oxidative damage: an update on medicinal chemistry and biological activity of stobadine and related pyridoindoles. Curr Med Chem 17: 552-570pl_PL
dc.referencesKagan VE, Tsuchiya M, Serbinova E, Packer L, Sies H. (1993). Interaction of the pyridoindole stobadine with peroxyl, superoxide and chromanoxyl radicals. Biochem Pharmacol 45: 393-400pl_PL
dc.referencesKalyanaraman B, Darley-Usmar V, Davies KJ, Dennery PA, Forman HJ, Grisham MB, Mann GE, Moore K, Roberts LJ 2nd, Ischiropoulos H. (2012). Measuring reactive oxygen and nitrogen species with fluorescent probes: challenges and limitations. Free Radic Biol Med 52 (1): 1-6pl_PL
dc.referencesRackova L, Cumaoglu A, Bagriacik EU, Stefek M, Maechler P, Karasu C. (2011). Novel hexahydropyridoindole derivative as prospective agent against oxidative damage in pancreatic β cells. Med Chem 7: 711-717pl_PL
dc.referencesRackova L, Snirc V, Jung T, Stefek M, Karasu C, Grune T. (2009). Metabolisminduced oxidative stress is a mediator of glucose toxicity in HT22 neuronal cells. Free Radic Res 43: 876-886pl_PL
dc.referencesRackova L, Snirc V, Majekova M, Majek P, Stefek M. (2006). Free radical scavenging and antioxidant activities of substituted hexahydropyridoindoles. Quantitative structure-activity relationships. J Med Chem 49: 2543-2548pl_PL
dc.referencesRackova L, Stefek M, Majekova M. (2002). Structural aspects of antioxidant activity of substituted pyridoindoles. Redox Rep 7(4): 207-214pl_PL
dc.referencesSotnikova R, Nedelcevova J, Navarova J, Nosalova V, Drabikova K, Szocs K, Krenek P, Kyselova Z, Bezek S, Knezl V, Drimal J, Broskova Z, Kristova V, Okruhlicova L, Bernatova I, Bauer V. (2011). Protection of the vascular endothelium in experimental situations. Interdiscip Toxicol 4: 20-26pl_PL
dc.referencesSpadafora-Ferreira M, Lopes AA, Coelho V, Guilherme L, Kalil J. (2000). Two novel anti-von Willebrand factor monoclonal antibodies. Thromb Res 97: 3-13pl_PL
dc.referencesSteenken S, Sunquist AR, Jovanovic SV, Crockett R, Sies H. (1992). Antioxidant activity of the pyridoindole stobadine. Pulse radiolytic characterization of one-electron-oxidized stobadine and quenching of singlet molecular oxygen. Chem Res Toxicol 5: 355-360pl_PL
dc.referencesStefek M, Masarykova M, Benes L. (1992). Inhibition of cumene hydroperoxide- induced lipid peroxidation by a novel pyridoindole antioxidant in rat liver microsomes. Pharmacol Toxicology 70: 407-411pl_PL
dc.referencesStefek M, Milackova I, Juskova-Karasova M, Snirc V. (2013). Antioxidant action of the hexahydropyridoindole SMe1EC2 in the cellular system of isolated red blood cells in vitro. Redox Rep 18(2): 71-75pl_PL
dc.referencesStefek M, Trnkova Z. (1996). The pyridoindole antioxidant stobadine prevents alloxan-induced lipid peroxidation by inhibiting its propagation. Pharmacology and Toxicology 78: 77-81pl_PL
dc.referencesStolc S, Povazanec F, Bauer V, Majekova M, Wilcox AL, Snirc V, Rackova L, Sotnikova R, Stefek M, Gasparova-Kvaltinova Z, Gajdosikova A, Mihalova D. (2010). Pyridoindole derivatives with antioxidant properties: synthesis, therapy and pharmaceutical remedies. Slovak Patent Agency: P 287506pl_PL
dc.referencesStolc S, Snirc V, Gajdosikova A, Gajdosik A, Gasparova Z, Ondrejickova O, Sotnikova R, Viola A, Rapta P, Jariabka P, Synekova I, Vajdova M, Zacharova S, Nemcek V, Krchnarova V. (2008) New pyridoindoles with antioxidant and neuroprotective actions. In Trends in Pharmacological Research Bauer, V. Ed. Institute of Experimental Pharmacology: Bratislava, 118-136pl_PL
dc.referencesStolc S, Snirc V, Majekova M, Gasparova Z, Gajdosikova A, Stvrtina S. (2006). Development of the new group of indole-derived neuroprotective drugs affecting oxidative stress. Cell Mol Neurobiol 26(7-8): 1495-1504pl_PL
dc.referencesUjhazy E, Dubovicky M, Ponechalova V, Navarova J, Brucknerova I, Snirc V, Mach M. (2008) Prenatal developmental toxicity study of the pyridoindole antioxidant SMe1EC2 in rats. Neuro Endocrinol Lett 29(5): 639-643pl_PL
dc.referencesUjhazy E, Mach M, Navarova J, Brucknerova I, Dubovicky M. (2011) Safety assessment of the pyridoindole derivative SMe1EC2: developmental neurotoxicity study in rats. Interdiscip Toxicol 4(1):47-51pl_PL
dc.referencesZurova-Nedelcevova J, Navarova J, Drabikova K, Jancinova V, Petrikova M, Bernatova I, Kristova V, Snirc V, Nosalova V, Sotnikova R. (2006) Participation of reactive oxygen species in diabetes-induced endothelial dysfunction. Neuro Endocrinol Lett 27(Suppl.2): 168-171pl_PL
dc.contributor.authorEmailmilan.stefek@savba.skpl_PL
dc.identifier.doi10.2478/intox-2014-0005
dc.relation.volume7pl_PL


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