| dc.contributor.author | Kowalczyk, Tomasz | |
| dc.contributor.author | Sitarek, Przemysław | |
| dc.contributor.author | Skała, Ewa | |
| dc.contributor.author | Rijo, Patrícia Dias de Mendonça | |
| dc.contributor.author | Andrade, Joana | |
| dc.contributor.author | Synowiec, Ewelina | |
| dc.contributor.author | Szemraj, Janusz | |
| dc.contributor.author | Krajewska, Urszula | |
| dc.contributor.author | Śliwiński, Tomasz | |
| dc.date.accessioned | 2019-12-12T07:52:47Z | |
| dc.date.available | 2019-12-12T07:52:47Z | |
| dc.date.issued | 2019-10-16 | |
| dc.identifier.issn | 1942-0994 | |
| dc.identifier.uri | http://hdl.handle.net/11089/31053 | |
| dc.description.abstract | Menyanthes trifoliata L. is a valuable medical plant found in Europe, North America, and Asia, which grows on peat bogs and
swamps. It has long been used in folk medicine as a remedy for various ailments. This is the first report to demonstrate the
protective antioxidant and anti-inflammatory properties of aqueous methanolic extracts derived from the aerial parts (MtAPV)
and roots (MtRV) of in vitro grown plants on human umbilical vein endothelial cells (HUVECs). It describes the influence of
the tested extracts on the expression of antioxidant (HO-1, NQO1, NRF2, kEAP1, and GCLC) and inflammation-related genes
(IL-1α, IL-1β, IL-6, TNF-α, and IFN-γ) in cells stimulated with H2O2 or LPS, respectively. In addition, M. trifoliata extracts were
found to moderately affect the growth of certain bacterial and fungal pathogens, with the strongest antibacterial effect found
against Pseudomonas aeruginosa and Enterococcus faecalis. M. trifoliata extracts demonstrated protective effects against
mitochondrial DNA (mtDNA) and nuclear DNA (nDNA) damage caused by ROS, decreasing the numbers of mtDNA lesions
in the ND1 and ND2 genes and nDNA damage in the TP53 and HPRT1 genes and reducing cleavage in PARP1- and γ-H2A.Xpositive
cells. The root extract of in vitro M. trifoliata (MtRV) appears to have better anti-inflammatory, antioxidant,
antimicrobial, and protective properties than the extract from the aerial part (MtAPV). These differences in biological properties
may result from the higher content of selected phenolic compounds and betulinic acid in the MtRV than in the MtAPV extract.
1. Introduction
Health-promoting properties of plants have been used in the
prevention and therapy of many human diseases for thousands
of years. Currently, it is estimated that 300,000 plant
species exist worldwide [1]; however, relatively few have confirmed
therapeutic or protective properties. Fortunately,
modern methods and equipment allow much faster and
Hindawi
Oxidative Medicine and Cellular Longevity
Volume 2019, Article ID 9165784, 13 pages
https://doi.org/10.1155/2019/9165784 | pl_PL |
| dc.description.sponsorship | University of Lodz Statutory
Funding Grant Number B1711000000201.01. | pl_PL |
| dc.language.iso | en | pl_PL |
| dc.publisher | Hindawi | pl_PL |
| dc.relation.ispartofseries | Oxidative Medicine and Cellular Longevity; | |
| dc.title | An Evaluation of the DNA-Protective Effects of Extracts from Menyanthes trifoliata L. Plants Derived from In Vitro Culture Associated with Redox Balance and Other Biological Activities | pl_PL |
| dc.type | Article | pl_PL |
| dc.page.number | 1-13 | pl_PL |
| dc.contributor.authorAffiliation | Department of Molecular Biotechnology and Genetics, University of Lodz, Banacha 12/16, 90-237 Lodz, Poland | pl_PL |
| dc.contributor.authorAffiliation | Department of Biology and Pharmaceutical Botany, Medical University of Lodz, Muszynskiego 1, 90-151 Lodz, Poland | pl_PL |
| dc.contributor.authorAffiliation | Center for Research in Biosciences and Health Technologies (CBIOS), Universidade Lusófona de Humanidades e Tecnologias, 1749-024 Lisbon, Portugal | pl_PL |
| dc.contributor.authorAffiliation | Instituto de Investigação do Medicamento (iMed.ULisboa), Faculdade de Farmácia, Universidade de Lisboa, 1649-003 Lisbon, Portugal | pl_PL |
| dc.contributor.authorAffiliation | Laboratory of Medical Genetics, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141/143, 90-236 Lodz, Poland | pl_PL |
| dc.contributor.authorAffiliation | Department of Medical Biochemistry, Medical University of Lodz, Mazowiecka 6/8, 92-215 Lodz, Poland | pl_PL |
| dc.contributor.authorAffiliation | Department of Pharmaceutical Biochemistry, Molecular Biology Laboratory, Medical University of Lodz, Muszynskiego 1, 90-151 Lodz, Poland | pl_PL |
| dc.identifier.eissn | 1942-0994 | |
| dc.references | C. Mora, D. P. Tittensor, S. Adl, A. G. B. Simpson, and B. Worm, “How many species are there on earth and in the ocean?,” PLoS Biology, vol. 9, no. 8, article e1001127, 2011. | pl_PL |
| dc.references | X. Liu, K. Vrieling, and P. G. L. Klinkhamer, “Interactions between plant metabolites affect herbivores: a study with pyrrolizidine alkaloids and chlorogenic acid,” Frontiers in Plant Science, vol. 8, p. 903, 2017. | pl_PL |
| dc.references | S. Latif, G. Chiapusio, and L. A. Weston, “Allelopathy and the role of allelochemicals in plant defence,” Advances in Botanical Research, vol. 82, pp. 19–54, 2017. | pl_PL |
| dc.references | J. Reichling, “Plant-Microbe Interactions and Secondary Metabolites with Antibacterial, Antifungal and Antiviral Properties,” in Functions and biotechnology of plant secondary metabolites, vol. 39, pp. 214–347, Blackwell, Oxford, UK, 2nd edition, 2010. | pl_PL |
| dc.references | A. G. Atanasov, B. Waltenberger, E. M. Pferschy-Wenzig et al., “Discovery and resupply of pharmacologically active plantderived natural products: a review,” Biotechnology Advances, vol. 33, no. 8, pp. 1582–1614, 2015. | pl_PL |
| dc.references | H. Yang, T. Tian, D. Wu, D. Guo, and J. Lu, “Prevention and treatment effects of edible berries for three deadly diseases: cardiovascular disease, cancer and diabetes,” Critical Reviews in Food Science and Nutrition, vol. 59, no. 12, pp. 1903–1912, 2019. | pl_PL |
| dc.references | F. L. Thompson, L. A. Hermanutz, and D. J. Innes, “The reproductive ecology of island populations of distylous Menyanthes trifoliata (Menyanthaceae),” Canadian Journal of Botany, vol. 76, no. 5, pp. 818–828, 1998. | pl_PL |
| dc.references | T. Kowalczyk, P. Sitarek, E. Skała et al., “Induction of apoptosis by in vitro and in vivo plant extracts derived from Menyanthes trifoliata L. in human cancer cells,” Cytotechnology, vol. 71, no. 1, pp. 165–180, 2019. | pl_PL |
| dc.references | J. Kuduk-Jaworska, J. Szpunar, K. Gąsiorowski, and B. Brokos, “Immunomodulating polysaccharide fractions of Menyanthes trifoliata L.,” Zeitschrift für Naturforschung C, vol. 59, no. 7-8, pp. 485–493, 2004. | pl_PL |
| dc.references | H. Tunón, L. Bohlin, and G. Öjteg, “The effect of Menyanthes trifoliata L. on acute renal failure might be due to PAF-inhibition,” Phytomedicine, vol. 1, no. 1, pp. 39–45, 1994. | pl_PL |
| dc.references | F. Martz, M. Turunen, R. Julkunen-Tiitto, K. Lakkala, and M. L. Sutinen, “Effect of the temperature and the exclusion of UVB radiation on the phenolics and iridoids in Menyanthes trifoliata L. leaves in the subarctic,” Environmental Pollution, vol. 157, no. 12, pp. 3471–3478, 2009. | pl_PL |
| dc.references | S. H. Lim, E. S. Jeon, J. Lee, S. Y. Han, and H. Chae, “Pharmacognostic outlooks on medical herbs of Sasang typology,” Integrative Medicine Research, vol. 6, no. 3, pp. 231–239, 2017. | pl_PL |
| dc.references | R. Gautam, M. Singh, S. Gautam, J. K. Rawat, S. A. Saraf, and G. Kaithwas, “Rutin attenuates intestinal toxicity induced by methotrexate linked with anti-oxidative and antiinflammatory effects,” BMC Complementary and Alternative Medicine, vol. 16, no. 1, p. 99, 2016. | pl_PL |
| dc.references | L. Wang, H. L. Wu, X. L. Yin, Y. Hu, H. W. Gu, and R. Q. Yu, “Simultaneous determination of umbelliferone and scopoletin in Tibetan medicine Saussurea laniceps and traditional Chinese medicine Radix angelicae pubescentis using excitationemission matrix fluorescence coupled with second-order calibration method,” Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, vol. 170, pp. 104–110, 2017. | pl_PL |
| dc.references | P. Sitarek, E. Skała, M. Toma et al., “Transformed root extract of Leonurus sibiricus induces apoptosis through intrinsic and extrinsic pathways in various grades of human glioma cells,” Pathology Oncology Research, vol. 23, no. 3, pp. 679–687, 2017. | pl_PL |
| dc.references | T. D. Schmittgen and K. J. Livak, “Analyzing real-time PCR data by the comparative CT method,” Nature Protocols, vol. 3, no. 6, pp. 1101–1108, 2008. | pl_PL |
| dc.references | O. Rothfuss, T. Gasser, and N. Patenge, “Analysis of differential DNA damage in the mitochondrial genome employing a semi-long run real-time PCR approach,” Nucleic Acids Research, vol. 38, no. 4, article e24, 2010. | pl_PL |
| dc.references | P. Sitarek, E. Synowiec, T. Kowalczyk, T. Śliwiński, and E. Skała, “An in vitro estimation of the cytotoxicity and genotoxicity of root extract from Leonurus sibiricus L. overexpressing AtPAP1 against different cancer cell lines,” Molecules, vol. 23, no. 8, article 2049, 2018. | pl_PL |
| dc.references | P. Sitarek, P. Rijo, C. Garcia et al., “Antibacterial, anti-inflammatory, antioxidant, and antiproliferative properties of essential oils from hairy and normal roots of Leonurus sibiricus L. and their chemical composition,” Oxidative Medicine and Cellular Longevity, vol. 2017, Article ID 7384061, 12 pages, 2017. | pl_PL |
| dc.references | H. Tunón, C. Olavsdotter, and L. Bohlin, “Evaluation of antiinflammatory activity of some Swedish medicinal plants. Inhibition of prostaglandin biosynthesis and PAF-induced exocytosis,” Journal of Ethnopharmacology, vol. 48, no. 2, pp. 61– 76, 1995. | pl_PL |
| dc.references | J. D. Rosenblat, D. S. Cha, R. B. Mansur, and R. S. McIntyre, “Inflamed moods: a review of the interactions between inflammation and mood disorders,” Progress in NeuroPsychopharmacology & Biological Psychiatry, vol. 53, pp. 23–34, 2014. | pl_PL |
| dc.references | N.P.Babu,P.Pandikumar,andS.Ignacimuthu,“Anti-inflammatory activity of Albizia lebbeck Benth., an ethnomedicinal plant, in acute and chronic animal models of inflammation,” Journal of Ethnopharmacology, vol. 125, no. 2, pp. 356–360, 2009. | pl_PL |
| dc.references | A. U. Ahmed, “An overview of inflammation: mechanism and consequences,” Frontiers of Biology in China, vol. 6, p. 274, 2011. | pl_PL |
| dc.references | A.’a. Al-Bakheit, S. Abu-Romman, A. Sharab, and M. Al Shhab, “Anti-inflammatory effect of Varthemia iphionoides extracts against prostate cancer in vitro,” European Journal of Inflammation, vol. 15, no. 1, pp. 8–14, 2017. | pl_PL |
| dc.references | C. Ma, L. Zhu, J. Wang et al., “Anti-inflammatory effects of water extract of Taraxacum mongolicum hand.-Mazz on lipopolysaccharide-induced inflammation in acute lung injury by suppressing PI3K/Akt/mTOR signaling pathway,” Journal of Ethnopharmacology, vol. 168, pp. 349–355, 2015. | pl_PL |
| dc.references | S. A. Adebayo, J. P. Dzoyem, L. J. Shai, and J. N. Eloff, “The anti-inflammatory and antioxidant activity of 25 plant species used traditionally to treat pain in southern African,” BMC Complementary and Alternative Medicine, vol. 15, no. 1, p. 159, 2015. | pl_PL |
| dc.references | H. Fang, R. A. Pengal, X. Cao et al., “Lipopolysaccharideinduced macrophage inflammatory response is regulated by SHIP,” Journal of Immunology, vol. 173, no. 1, pp. 360–366, 2004. | pl_PL |
| dc.references | P. Mizgier, A. Z. Kucharska, A. Sokół-Łętowska, J. KolniakOstek, M. Kidoń, and I. Fecka, “Characterization of phenolic compoundsandantioxidantandanti-inflammatoryproperties of red cabbage and purple carrot extracts,” Journal of Functional Foods, vol. 21, pp. 133–146, 2016. | pl_PL |
| dc.references | M. J. Rodrigues, V. Neves, A. Martins et al., “In vitro antioxidant and anti-inflammatory properties of Limonium algarvense flowers’ infusions and decoctions: a comparison with green tea (Camellia sinensis),” Food Chemistry, vol. 200, pp. 322–329, 2016. | pl_PL |
| dc.references | M. H. Grace, D. Esposito, M. A. Timmers et al., “Chemical composition, antioxidant and anti-inflammatory properties of pistachio hull extracts,” Food Chemistry, vol. 210, pp. 85– 95, 2016. | pl_PL |
| dc.references | J. J. Yoon, Y. J. Lee, J. S. Kim, D. G. Kang, and H. S. Lee, “Protective role of betulinic acid on TNF-α-induced cell adhesion molecules in vascular endothelial cells,” Biochemical and Biophysical Research Communications, vol. 391, no. 1, pp. 96–101, 2010. | pl_PL |
| dc.references | W. T. Wu, M. C. Mong, Y. C. Yang, Z. H. Wang, and M. C. Yin, “Aqueous andethanol extracts of daylily flower (Hemerocallis fulva L.) protect HUVE cells against high glucose,” Journal of Food Science, vol. 83, no. 5, pp. 1463–1469, 2018. | pl_PL |
| dc.references | B.Zdzisińska,W.Rzeski,R.Paduchetal.,“Differentialeffectof betulin and betulinic acid on cytokine production in human whole blood cell cultures,” Polish Journal of Pharmacology, vol. 55, no. 2, pp. 235–238, 2003. | pl_PL |
| dc.references | K. S. Kim, D. S. Lee, D. C. Kim et al., “Anti-inflammatory effects and mechanisms of action of coussaric and betulinic acids isolated from diospyros kaki in lipopolysaccharidestimulated RAW 264.7 macrophages,” Molecules, vol. 21, no. 9, article 1206, 2016. | pl_PL |
| dc.references | X. Huang, Q. Pan, Z. Mao et al., “Sinapic acid inhibits the IL1β-induced inflammation via MAPK downregulation in rat chondrocytes,” Inflammation, vol. 41, no. 2, pp. 562–568, 2018. | pl_PL |
| dc.references | K. J. Yun, D. J. Koh, S. H. Kim et al., “Anti-inflammatory effects of sinapic acid through the suppression of inducible nitric oxide synthase, cyclooxygase-2, and proinflammatory cytokines expressions via nuclear factor-κB inactivation,” Journal of Agricultural and Food Chemistry, vol. 56, no. 21, pp. 10265–10272, 2008. | pl_PL |
| dc.references | M.Jayachandran,R.Vinayagam,R.R.Ambati,B.Xu,andS.S. M. Chung, “Guava leaf extract diminishes hyperglycemia and oxidative stress, prevents β-cell death, inhibits inflammation, and regulates NF-κB signaling pathway in STZ induceddiabetic rats,” BioMed Research International, vol. 2018, Article ID 4601649, 14 pages, 2018. | pl_PL |
| dc.references | J. H. Lee, J. H. Won, J. M. Choi et al., “Protective effect of ellagic acid on concanavalin A-induced hepatitis via toll-like receptor and mitogen-activated protein kinase/nuclear factor κb signaling pathways,” Journal of Agricultural and Food Chemistry, vol. 62, no. 41, pp. 10110–10117, 2014. | pl_PL |
| dc.references | S. J. Hwang, Y. W. Kim, Y. Park, H. J. Lee, and K. W. Kim, “Anti-inflammatory effects of chlorogenic acid in lipopolysaccharide-stimulated RAW 264.7 cells,” Inflammation Research, vol. 63, no. 1, pp. 81–90, 2014. | pl_PL |
| dc.references | V. A. Kostyuk, A. I. Potapovich, T. O. Suhan, C. De Luca, and L. G. Korkina, “Antioxidant and signal modulation properties of plant polyphenols in controlling vascular inflammation,” European Journal of Pharmacology, vol. 658, no. 2-3, pp. 248–256, 2011. | pl_PL |
| dc.references | M. De La Luz Cádiz-Gurrea, I. Borrás-Linares, J. LozanoSánchez, J. Joven, S. Fernández-Arroyo, and A. SeguraCarretero, “Cocoa and grape seed byproducts as a source of antioxidant and anti-inflammatory proanthocyanidins,” International Journal of Molecular Sciences, vol. 18, no. 2, p. 376, 2017. | pl_PL |
| dc.references | M. S. Karimian, M. Pirro, M. Majeed, and A. Sahebkar, “Curcumin as a natural regulator of monocyte chemoattractant protein-1,” Cytokine and Growth Factor Reviews, vol. 33, pp. 55–63, 2017. | pl_PL |
| dc.references | P. Pullikotil, H. Chen, R. Muniyappa et al., “Epigallocatechin gallate induces expression of heme oxygenase-1 in endothelial cells via p38 MAPK and Nrf-2 that suppresses proinflammatory actions of TNF-α,” The Journal of Nutritional Biochemistry, vol. 23, no. 9, pp. 1134–1145, 2012. | pl_PL |
| dc.references | V. K. Bajpai, M. B. Alam, M. K. Ju et al., “Antioxidant mechanism of polyphenol-rich Nymphaea nouchali leaf extract protecting DNA damage and attenuating oxidative stress-induced cell death via Nrf2-mediated heme-oxygenase1 induction coupled with ERK/p38 signaling pathway,” Biomedicine & Pharmacotherapy, vol. 103, pp. 1397–1407, 2018. | pl_PL |
| dc.references | A. I. Casas, V. T. V. Dao, A. Daiber et al., “Reactive oxygenrelateddiseases:therapeutictargetsandemergingclinicalindications,” Antioxidants & Redox Signaling, vol. 23, no. 14, pp. 1171–1185, 2015. | pl_PL |
| dc.references | M. Mittal, M. R. Siddiqui, K. Tran, S. P. Reddy, and A. B. Malik, “Reactive oxygen species in inflammation and tissue injury,” Antioxidants & Redox Signaling, vol. 20, no. 7, pp. 1126–1167, 2014. | pl_PL |
| dc.references | S. Manoharan, G. J. Guillemin, R. S. Abiramasundari, M. M. Essa, M.Akbar, andM. D.Akbar, “Theroleof reactive oxygen species in thepathogenesisof Alzheimer’sdisease, Parkinson’s disease, and Huntington’s disease: a mini review,” Oxidative Medicine and Cellular Longevity, vol. 2016, Article ID 8590578, 15 pages, 2016. | pl_PL |
| dc.references | F. Festa, T. Aglitti, G. Duranti, R. Ricordy, P. Perticone, and R. Cozzi, “Strong antioxidant activity of ellagic acid in mammalian cells in vitro revealed by the comet assay,” Anticancer Research, vol. 21, no. 6A, pp. 3903–3908, 2001. | pl_PL |
| dc.references | K. Sevgi, B. Tepe, and C. Sarikurkcu, “Antioxidant and DNA damage protection potentials of selected phenolic acids,” Food and Chemical Toxicology, vol. 77, pp. 12–21, 2015. | pl_PL |
| dc.references | S.R.Abbas,S.M.Sabir,S.D.Ahmad,A.A.Boligon, andM.L. Athayde, “Phenolic profile, antioxidant potential and DNA damage protecting activity of sugarcane (Saccharum officinarum),” Food Chemistry, vol. 147, pp. 10–16, 2014. | pl_PL |
| dc.references | P. Singh, S. P. Vishwakarma, and R. L. Singh, “Antioxidant, oxidative DNA damage protective and antimicrobial activities of the plant Trigonella foenum-graecum,” Journal of the Science of Food and Agriculture, vol. 94, no. 12, pp. 2497– 2504, 2014. | pl_PL |
| dc.references | K. Kozics, V. Klusová, A. Srančíková et al., “Effects of Salvia officinalis and Thymus vulgaris on oxidant-induced DNA damage and antioxidant status in HepG2 cells,” Food Chemistry, vol. 141, no. 3, pp. 2198–2206, 2013. | pl_PL |
| dc.references | A. C. Dametto, D. Agustoni, T. F. Moreira et al., “Chemical composition and in vitro chemoprevention assessment of Eugenia jambolana Lam. (Myrtaceae) fruits and leaves,” Journal of Functional Foods, vol. 36, pp. 490–502, 2017. | pl_PL |
| dc.references | S. Schaefer, M. Baum, G. Eisenbrand, H. Dietrich, F. Will, and C. Janzowski, “Polyphenolic apple juice extracts and their major constituents reduce oxidative damage in human colon cell lines,” Molecular Nutrition & Food Research, vol. 50, no. 1, pp. 24–33, 2006. | pl_PL |
| dc.references | S. Schaefer, M. Baum, G. Eisenbrand, H. Dietrich, F. Will, and C. Janzowski, “Polyphenolic apple juice extracts and their major constituents reduce oxidative damage in human colon cell lines,” Molecular Nutrition & Food Research, vol. 50, no. 1, pp. 24–33, 2006. | pl_PL |
| dc.references | F. Guglielmi, C. Luceri, L. Giovannelli, P. Dolara, and M. Lodovici, “Effect of 4-coumaric and 3,4-dihydroxybenzoic acid on oxidative DNA damage in rat colonic mucosa,” The British Journal of Nutrition, vol. 89, no. 5, pp. 581–587, 2003. | pl_PL |
| dc.references | C. H. Tsai, S. F. Tzeng, S. C. Hsieh et al., “A standardized Wedelia chinensis extract overcomes the feedback activation of HER2/3 signaling upon androgen-ablation in prostate cancer,” Frontiers in Pharmacology, vol. 8, p. 721, 2017. | pl_PL |
| dc.references | C.SoldaniandA.I.Scovassi,“Poly(ADP-ribose)polymerase-1 cleavage during apoptosis: an update,” Apoptosis, vol. 7, no. 4, pp. 321–328, 2002. | pl_PL |
| dc.references | H. Wei and X. Yu, “Functions of PARylation in DNA damage repair pathways,” Genomics, Proteomics & Bioinformatics, vol. 14, no. 3, pp. 131–139, 2016. | pl_PL |
| dc.references | L. J. Kuo and L. X. Yang, “Gamma-H2AX - a novel biomarker for DNA double-strand breaks,” In Vivo, vol. 22, no. 3, pp. 305–309, 2008. | pl_PL |
| dc.references | M. Hausmann, E. Wagner, J. H. Lee et al., “Super-resolution localization microscopy of radiation-induced histone H2AXphosphorylation in relation to H3K9-trimethylation in HeLa cells,” Nanoscale, vol. 10, no. 9, pp. 4320–4331, 2018. | pl_PL |
| dc.references | C.Y.Lin, P.N.Chen, Y.S.Hsieh, andS. C.Chu, “Koelreuteria formosana extract impedes in vitro human LDL and prevents oxidised LDL-induced apoptosis in human umbilical vein endothelialcells,”FoodChemistry,vol.146,pp.299–307,2014. | pl_PL |
| dc.references | H. Chang, W. Yuan, H. Wu, X. Yin, and H. Xuan, “Bioactive components and mechanisms of Chinese poplar propolis alleviates oxidized low-density lipoprotein-induced endothelial cells injury,” BMC Complementary and Alternative Medicine, vol. 18, no. 1, p. 142, 2018. | pl_PL |
| dc.references | S. He, R. Ou, W. Wang et al., “Camptosorus sibiricus rupr aqueous extract prevents lung tumorigenesis via dual effects against ROS and DNA damage,” Journal of Ethnopharmacology, vol. 220, pp. 44–56, 2018. | pl_PL |
| dc.references | R. S. Carvalho, C. A. Carollo, J. C. de Magalhães et al., “Antibacterial and antifungal activities of phenolic compoundenriched ethyl acetate fraction from Cochlospermum regium (mart. Et. Schr.) Pilger roots: mechanisms of action and synergism with tannin and gallic acid,” South African Journal of Botany, vol. 114, pp. 181–187, 2018. | pl_PL |
| dc.references | R. R. Chand, A. D. Jokhan, R. D. Gopalan, and T. Osborne, “Antibacterial and antifungal activities of essential oils from medicinalplantsfound intheSouthPacific,” TheSouthPacificJournal of Natural and Applied Sciences, vol. 35, no. 1, pp. 10– 19, 2017. | pl_PL |
| dc.references | K. Bashir Dar, A. Hussain Bhat, S. Amin et al., “Evaluation of antibacterial, antifungal and phytochemical screening of Solanum nigrum,” Biochemistry & Analytical Biochemistry, vol. 6, no. 1, p. 309, 2017. | pl_PL |
| dc.references | E. Ivanišová, T. Krajčovič, M. Tokár, Š. Dráb, A. Kántor, and M.Kačániová,“Potentialofwildplantsasasourceofbioactive compounds,” Animal Science & Biotechnologies, vol. 50, pp. 109–114, 2017. | pl_PL |
| dc.references | B. Paudel, H. D. Bhattarai, I. C. Kim et al., “Estimation of antioxidant, antimicrobial activity and brine shrimp toxicity of plants collected from Oymyakon region of the republic of Sakha (Yakutia), Russia,” Biological Research, vol. 47, no. 1, p. 10, 2014. | pl_PL |
| dc.references | C. S. Rempe, K. P. Burris, S. C. Lenaghan, and C. N. Stewart, “The potential of systems biology to discover antibacterial mechanisms of plant phenolics,” Frontiers in Microbiology, vol. 8, p. 422, 2017. | pl_PL |
| dc.references | H. O. B. Oloyede, H. O. Ajiboye, M. O. Salawu, and T. O. Ajiboye, “Influence of oxidative stress on the antibacterial activity of betulin, betulinic acid and ursolic acid,” Microbial Pathogenesis, vol. 111, pp. 338–344, 2017. | pl_PL |
| dc.references | G. M. Woldemichael, M. P. Singh, W. M. Maiese, and B. N. Timmermann,“ConstituentsofantibacterialextractofCaesalpinia paraguariensis Burk,” Zeitschrift für Naturforschung C, vol. 58, no. 1-2, pp. 70–75, 2003. | pl_PL |
| dc.references | C. Chandramu, R. D. Manohar, D. G. L. Krupadanam, and R. V. Dashavantha, “Isolation, characterization and biological activity of betulinic acid and ursolic acid from Vitex negundo L,” Phytotherapy Research, vol. 17, no. 2, pp. 129–134, 2003. | pl_PL |
| dc.references | L. Catteau, L. Zhu, F. Van Bambeke, and J. Quetin-Leclercq, “Naturalandhemi-syntheticpentacyclictriterpenesasantimicrobials and resistance modifying agents against Staphylococcus aureus: a review,” Phytochemistry Reviews, vol. 17, no. 5, pp. 1129–1163, 2018. | pl_PL |
| dc.references | T. Wu, X. Zang, M. He, S. Pan, and X. Xu, “Structure–activity relationship of flavonoids on their anti-Escherichia coli activity and inhibition of DNA gyrase,” Journal of Agricultural and Food Chemistry, vol. 61, no. 34, pp. 8185–8190, 2013. | pl_PL |
| dc.references | S. Khan, T. Ur-Rehman, B. Mirza, I. Ul-Haq, and M. Zia, “Antioxidant, antimicrobial, cytotoxic and protein kinase inhibitionactivitiesof fifteentraditionalmedicinalplantsfrom Pakistan,” Pharmaceutical Chemistry Journal, vol. 51, no. 5, pp. 391–398, 2017. | pl_PL |
| dc.references | C.Willyard,“Thedrug-resistantbacteriathatposethegreatest health threats,” Nature, vol. 543, no. 7643, p. 15, 2017. | pl_PL |
| dc.contributor.authorEmail | tomasz.kowalczyk@biol.uni.lodz.pl | pl_PL |
| dc.identifier.doi | 10.1155/2019/9165784 | |
| dc.relation.volume | 2019 | pl_PL |
| dc.discipline | nauki biologiczne | pl_PL |
