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The Tobacco Smoke Component, Acrolein, as a Major Culprit in Lung Diseases and Respiratory Cancers: Molecular Mechanisms of Acrolein Cytotoxic Activity

dc.contributor.authorHikisz, Paweł
dc.contributor.authorJacenik, Damian
dc.date.accessioned2023-06-19T12:10:29Z
dc.date.available2023-06-19T12:10:29Z
dc.date.issued2023
dc.identifier.citationHikisz, Pawel, and Damian Jacenik. 2023. "The Tobacco Smoke Component, Acrolein, as a Major Culprit in Lung Diseases and Respiratory Cancers: Molecular Mechanisms of Acrolein Cytotoxic Activity" Cells 12, no. 6: 879. https://doi.org/10.3390/cells12060879pl_PL
dc.identifier.urihttp://hdl.handle.net/11089/47293
dc.description.abstractAcrolein, a highly reactive unsaturated aldehyde, is a ubiquitous environmental pollutant that seriously threatens human health and life. Due to its high reactivity, cytotoxicity and genotoxicity, acrolein is involved in the development of several diseases, including multiple sclerosis, neurodegenerative diseases such as Alzheimer’s disease, cardiovascular and respiratory diseases, diabetes mellitus and even the development of cancer. Traditional tobacco smokers and e-cigarette users are particularly exposed to the harmful effects of acrolein. High concentrations of acrolein have been found in both mainstream and side-stream tobacco smoke. Acrolein is considered one of cigarette smoke’s most toxic and harmful components. Chronic exposure to acrolein through cigarette smoke has been linked to the development of asthma, acute lung injury, chronic obstructive pulmonary disease (COPD) and even respiratory cancers. This review addresses the current state of knowledge on the pathological molecular mechanisms of acrolein in the induction, course and development of lung diseases and cancers in smokers.pl_PL
dc.language.isoenpl_PL
dc.publisherMDPIpl_PL
dc.relation.ispartofseriesCells;6
dc.rightsUznanie autorstwa 4.0 Międzynarodowe*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectacroleinpl_PL
dc.subjectlung cancerpl_PL
dc.subjectinflammationpl_PL
dc.subjecttobacco smokepl_PL
dc.subjectCOPDpl_PL
dc.subjectrespiratory toxicitypl_PL
dc.subjectoxidative stresspl_PL
dc.subjectDNA adductspl_PL
dc.subjectcell signallingpl_PL
dc.subjectα,β-unsaturated aldehydespl_PL
dc.titleThe Tobacco Smoke Component, Acrolein, as a Major Culprit in Lung Diseases and Respiratory Cancers: Molecular Mechanisms of Acrolein Cytotoxic Activitypl_PL
dc.typeArticlepl_PL
dc.page.number28pl_PL
dc.contributor.authorAffiliationDepartment of Oncobiology and Epigenetics, Faculty of Biology and Environmental Protection, University of Lodz, ul. Pomorska 141/143, 90-236 Lodz, Polandpl_PL
dc.contributor.authorAffiliationDepartment of Cytobiochemistry, Faculty of Biology and Environmental Protection, University of Lodz, ul. Pomorska 141/143, 90-236 Lodz, Polandpl_PL
dc.identifier.eissn2073-4409
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dc.identifier.doi10.3390/cells12060879
dc.relation.volume12pl_PL
dc.disciplinenauki biologicznepl_PL


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