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Digit ratio (2D:4D), laryngeal cancer and vocal fold leukoplakia

dc.contributor.authorPietruszewska, Wioletta
dc.contributor.authorMorawska, Joanna
dc.contributor.authorManning, John T.
dc.contributor.authorSitek, Aneta
dc.contributor.authorAntoszewski, Bogusław
dc.contributor.authorKasielska-Trojan, Anna
dc.date.accessioned2023-06-19T12:18:38Z
dc.date.available2023-06-19T12:18:38Z
dc.date.issued2023
dc.identifier.citationPietruszewska, W., Morawska, J., Manning, J.T. et al. Digit ratio (2D:4D), laryngeal cancer and vocal fold leukoplakia. J Cancer Res Clin Oncol (2023). https://doi.org/10.1007/s00432-023-04850-8pl_PL
dc.identifier.issn0171-5216
dc.identifier.urihttp://hdl.handle.net/11089/47294
dc.description.abstractBackground - To date, there are no studies that have analyzed the possible influence of exposure to prenatal sex hormones on the risk of laryngeal cancer (LC) and premalignant laryngeal lesion—vocal fold leukoplakia (VFL). Digit ratio (2D:4D) is suggested to be a proxy of prenatal sex hormone exposure. Objective - To examine 2D:4D in patients with LC and clarify if it could add to the verified risk factors in estimating the overall risk of LC. Methods - 511 subjects participated in the study. The study group included 269 patients: with LC (N = 114, 64 men) and VFL (N = 155, 116 men). Controls included 242 healthy individuals (66.40 ± 4.50 years (106 men)). Results - Predictive models estimating the risk of VFL and LC in women, based solely on predictors like smoking and alcohol consumption had a lower area under the ROC curve (AUC) than the model with left 2D:4D. AUC for the model estimating the likelihood of VFL increased from 0.83 to 0.85, and for LC from 0.76 to 0.79. Conclusions - Low left 2D:4D may be associated with an increased risk of developing leukoplakia and laryngeal cancer in women. In the case of laryngeal cancer, left 2D:4D may serve as additional variable (to other known risk factors, such as smoking and/or alcohol consumption), which can improve cancer risk prediction.pl_PL
dc.language.isoenpl_PL
dc.publisherSpringer Naturepl_PL
dc.relation.ispartofseriesJournal of Cancer Research and Clinical Oncology;
dc.rightsUznanie autorstwa 4.0 Międzynarodowe*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectLaryngeal cancerpl_PL
dc.subjectLeukoplakiapl_PL
dc.subjectDigit ratiopl_PL
dc.subjectRisk factorspl_PL
dc.titleDigit ratio (2D:4D), laryngeal cancer and vocal fold leukoplakiapl_PL
dc.typeArticlepl_PL
dc.page.number11pl_PL
dc.contributor.authorAffiliationDepartment of Otolaryngology, Head and Neck Oncology, Medical University of Lodz, Lodz, Polandpl_PL
dc.contributor.authorAffiliationDepartment of Otolaryngology, Head and Neck Oncology, Medical University of Lodz, Lodz, Polandpl_PL
dc.contributor.authorAffiliationApplied Sports, Technology, Exercise, and Medicine (A‑STEM), Swansea University, Swansea, UKpl_PL
dc.contributor.authorAffiliationDepartment of Anthropology, University of Lodz, Lodz, Polandpl_PL
dc.contributor.authorAffiliationPlastic, Reconstructive and Aesthetic Surgery Clinic, Institute of Surgery, Medical University of Lodz, Kopcinskiego 22, 90‑153 Lodz, Polandpl_PL
dc.contributor.authorAffiliationPlastic, Reconstructive and Aesthetic Surgery Clinic, Institute of Surgery, Medical University of Lodz, Kopcinskiego 22, 90‑153 Lodz, Polandpl_PL
dc.identifier.eissn1432-1335
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dc.identifier.doi10.1007/s00432-023-04850-8
dc.disciplinenauki biologicznepl_PL


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Uznanie autorstwa 4.0 Międzynarodowe
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