Pokaż uproszczony rekord

Digit ratio (2D:4D), laryngeal cancer and vocal fold leukoplakia

dc.contributor.authorPietruszewska, Wioletta
dc.contributor.authorMorawska, Joanna
dc.contributor.authorManning, John T.
dc.contributor.authorSitek, Aneta
dc.contributor.authorAntoszewski, Bogusław
dc.contributor.authorKasielska-Trojan, Anna
dc.date.accessioned2023-06-19T12:18:38Z
dc.date.available2023-06-19T12:18:38Z
dc.date.issued2023
dc.identifier.citationPietruszewska, W., Morawska, J., Manning, J.T. et al. Digit ratio (2D:4D), laryngeal cancer and vocal fold leukoplakia. J Cancer Res Clin Oncol (2023). https://doi.org/10.1007/s00432-023-04850-8pl_PL
dc.identifier.issn0171-5216
dc.identifier.urihttp://hdl.handle.net/11089/47294
dc.description.abstractBackground - To date, there are no studies that have analyzed the possible influence of exposure to prenatal sex hormones on the risk of laryngeal cancer (LC) and premalignant laryngeal lesion—vocal fold leukoplakia (VFL). Digit ratio (2D:4D) is suggested to be a proxy of prenatal sex hormone exposure. Objective - To examine 2D:4D in patients with LC and clarify if it could add to the verified risk factors in estimating the overall risk of LC. Methods - 511 subjects participated in the study. The study group included 269 patients: with LC (N = 114, 64 men) and VFL (N = 155, 116 men). Controls included 242 healthy individuals (66.40 ± 4.50 years (106 men)). Results - Predictive models estimating the risk of VFL and LC in women, based solely on predictors like smoking and alcohol consumption had a lower area under the ROC curve (AUC) than the model with left 2D:4D. AUC for the model estimating the likelihood of VFL increased from 0.83 to 0.85, and for LC from 0.76 to 0.79. Conclusions - Low left 2D:4D may be associated with an increased risk of developing leukoplakia and laryngeal cancer in women. In the case of laryngeal cancer, left 2D:4D may serve as additional variable (to other known risk factors, such as smoking and/or alcohol consumption), which can improve cancer risk prediction.pl_PL
dc.language.isoenpl_PL
dc.publisherSpringer Naturepl_PL
dc.relation.ispartofseriesJournal of Cancer Research and Clinical Oncology;
dc.rightsUznanie autorstwa 4.0 Międzynarodowe*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectLaryngeal cancerpl_PL
dc.subjectLeukoplakiapl_PL
dc.subjectDigit ratiopl_PL
dc.subjectRisk factorspl_PL
dc.titleDigit ratio (2D:4D), laryngeal cancer and vocal fold leukoplakiapl_PL
dc.typeArticlepl_PL
dc.page.number11pl_PL
dc.contributor.authorAffiliationDepartment of Otolaryngology, Head and Neck Oncology, Medical University of Lodz, Lodz, Polandpl_PL
dc.contributor.authorAffiliationDepartment of Otolaryngology, Head and Neck Oncology, Medical University of Lodz, Lodz, Polandpl_PL
dc.contributor.authorAffiliationApplied Sports, Technology, Exercise, and Medicine (A‑STEM), Swansea University, Swansea, UKpl_PL
dc.contributor.authorAffiliationDepartment of Anthropology, University of Lodz, Lodz, Polandpl_PL
dc.contributor.authorAffiliationPlastic, Reconstructive and Aesthetic Surgery Clinic, Institute of Surgery, Medical University of Lodz, Kopcinskiego 22, 90‑153 Lodz, Polandpl_PL
dc.contributor.authorAffiliationPlastic, Reconstructive and Aesthetic Surgery Clinic, Institute of Surgery, Medical University of Lodz, Kopcinskiego 22, 90‑153 Lodz, Polandpl_PL
dc.identifier.eissn1432-1335
dc.referencesAlsahafi E, Begg K, Amelio I, Raulf N, Lucarelli P, Sauter T, Tavassoli M (2019) Clinical update on head and neck cancer: molecular biology and ongoing challenges. Cell Death Dis. https://doi.org/10.1038/s41419-019-1769-9pl_PL
dc.referencesAuger J, Le Denmat D, Berges R, Doridot L, Salmon B, Canivenc-Lavier MC, Eustache F (2013) Environmental levels of oestrogenic and antiandrogenic compounds feminize digit ratios in male rats and their unexposed male progeny. Proc Royal Soc Biol Sci 280(1768):10–17. https://doi.org/10.1098/rspb.2013.1532pl_PL
dc.referencesAvila DD, D’Ávila J, Góis C, Barretto L (2014) Premalignant laryngeal lesions: twenty-year experience in specialized service. Int Arch Otorhinolaryngol 18(4):352–356. https://doi.org/10.1055/s-0034-1376431pl_PL
dc.referencesBianchini C, Pastore A, Pelucchi S, Torreggiani E, Lambertini E, Marchesi E, Piva R (2008) Sex hormone receptor levels in laryngeal carcinoma: a comparison between protein and RNA evaluations. Eur Arch Otorhinolaryngol 265(9):1089–1094. https://doi.org/10.1007/s00405-008-0589-9pl_PL
dc.referencesBradford CR, Ferlito A, Devaney KO, Mäkitie AA, Rinaldo A (2020) Prognostic factors in laryngeal squamous cell carcinoma. Laryngoscope Investig Otolaryngol 5(1):74–81. https://doi.org/10.1002/lio2.353pl_PL
dc.referencesBray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A (2018) Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 68(6):394–424. https://doi.org/10.3322/caac.21492pl_PL
dc.referencesBunevicius A (2018) The Association of Digit Ratio (2D: 4D) with Cancer: a systematic review and meta-analysis. Dis Markers. https://doi.org/10.1155/2018/7698193pl_PL
dc.referencesBunevicius A, Tamasauskas S, Deltuva VP, Tamasauskas A, Sliauzys A, Bunevicius R (2016) Digit ratio (2D:4D) in primary brain tumor patients: a case-control study. Early Hum Dev 103:205–208. https://doi.org/10.1016/j.earlhumdev.2016.10.003pl_PL
dc.referencesChen M, Li C, Yang Y, Cheng L, Wu H (2019) A morphological classification for vocal fold leukoplakia. Braz J Otorhinolaryngol 85(5):588–596. https://doi.org/10.1016/j.bjorl.2018.04.014pl_PL
dc.referencesChu EA, Kim YJ (2008) Laryngeal cancer: diagnosis and preoperative work-up. Otolaryngol Clin North Am 41(4):673–695. https://doi.org/10.1016/j.otc.2008.01.016pl_PL
dc.referencesFonseca CAD, Martelli DRB, Maia CMF, Dias VO, Carvalho AA, Júnior HM (2022) Digital biomarker 2D:4D as a predictor of cancer: a systematic review. Early Hum Dev 164:105521. https://doi.org/10.1016/j.earlhumdev.2021.105521)pl_PL
dc.referencesFreedman ND, Chow WH, Gao YT, Shu XO, Ji BT, Yang G, Abnet CC (2007) Menstrual and reproductive factors and gastric cancer risk in a large prospective study of women. Gut 56(12):1671–1677. https://doi.org/10.1136/gut.2007.129411pl_PL
dc.referencesGaravello W, Turati F, Bosetti C, Talamini R, Levi F, Lucenteforte E, Negri E (2012) Family history of cancer and the risk of laryngeal cancer: a case-control study from Italy and Switzerland. Int J Cancer 130(3):665–670. https://doi.org/10.1002/ijc.26055pl_PL
dc.referencesGatta G, Capocaccia R, Botta L, Mallone S, De Angelis R, Ardanaz E, Benhamou E (2017) Burden and centralised treatment in Europe of rare tumours: results of RARECAREnet—a population-based study. Lancet Oncol 18(8):1022–1039. https://doi.org/10.1016/S1470-2045(17)30445-Xpl_PL
dc.referencesGlade MJ (1999) Food, nutrition, and the prevention of cancer: a global perspective. Nutrition 15(6):523–526. https://doi.org/10.1016/S0899-9007(99)00021-0pl_PL
dc.referencesGrotmol T, Weiderpass E, Tretli S (2006) Conditions in utero and cancer risk. Eur J Epidemiol 21(8):561–570. https://doi.org/10.1007/s10654-006-9036-7pl_PL
dc.referencesHagedorn HG, Nerlich AG (2002) Analysis of sex-hormone-receptor expression in laryngeal carcinoma. Eur Arch Otorhinolaryngol 259(4):205–210. https://doi.org/10.1007/s004050100400pl_PL
dc.referencesHanley JA, Hajian-Tilaki KO (1997) Sampling variability of nonparametric estimates of the areas under receiver operating characteristic curves: an update. Acad Radiol 4(1):49–58. https://doi.org/10.1016/S1076-6332(97)80161-4pl_PL
dc.referencesHönekopp J, Watson S (2010) Meta-analysis of digit ratio 2D:4D shows greater sex difference in the right hand. Am J Hum Biol 22(5):619–630. https://doi.org/10.1002/ajhb.21054pl_PL
dc.referencesHong L, Zhan-Bing M, Zhi-Yun S, Xiao-Xia S, Jun-Li Z, Zheng-Hao H (2014) Digit ratio (2D:4D) in Chinese women with breast cancer. Am J Hum Biol 26(4):562–564. https://doi.org/10.1002/ajhb.22546pl_PL
dc.referencesHopp RN, Lima NCdS, Filho MS, Filho JLF, Jorge J (2015) Digit ratio is associated with colorectal cancer. J Gastrointest Dig Syst 5:253. https://doi.org/10.4172/2161-069X.1000253pl_PL
dc.referencesHuang F, Yu J, Zhang F, He C, Li S, Shao J (2017) The usefulness of narrow-band imaging for the diagnosis and treatment of vocal fold leukoplakia. Acta Otolaryngol 137(9):1002–1006. https://doi.org/10.1080/00016489.2017.1324216pl_PL
dc.referencesJohnson DE, Burtness B, Leemans CR, Lui VWY, Bauman JE, Grandis JR (2020) Head and neck squamous cell carcinoma. Nat Rev Dis Primers. https://doi.org/10.1038/s41572-020-00224-3pl_PL
dc.referencesKasielska-Trojan A, Antoszewski B (2015) Can digit ratio (2D:4D) studies be helpful in explaining the aetiology of idiopathic gynecomastia? Early Human Dev 91(1):57–61pl_PL
dc.referencesKasielska-Trojan A, Manning JT, Antczak A, Dutkowska A, Kuczyński W, Sitek A, Antoszewski B (2020) Digit ratio (2D:4D) in women and men with lung cancer. Sci Rep 10(1):1–8. https://doi.org/10.1038/s41598-020-68239-0pl_PL
dc.referencesKostev K, Jacob L, Kalder M, Sesterhenn A, Seidel D (2018) Association of laryngeal cancer with vocal cord leukoplakia and associated risk factors in 1184 patients diagnosed in otorhinolaryngology practices in Germany. Mol Clin Oncol. https://doi.org/10.3892/mco.2018.1592pl_PL
dc.referencesLi X, Gao L, Li H, Gao J, Yang Y, Zhou F, Jin Q (2013) Human papillomavirus infection and laryngeal cancer risk: a systematic review and meta-analysis. J Infect Dis 207(3):479–488. https://doi.org/10.1093/infdis/jis698pl_PL
dc.referencesLi C, Zhang N, Wang S, Cheng L, Wu H, Chen J, Shi F (2018) A new classification of vocal fold leukoplakia by morphological appearance guiding the treatment. Acta Otolaryngol 138(6):584–589. https://doi.org/10.1080/00016489.2018.1425000pl_PL
dc.referencesLicitra L, Bernier J, Grandi C, Locati L, Merlano M, Gatta G, Lefebvre JL (2003) Cancer of the larynx. Crit Rev Oncol Hematol 47(1):65–80. https://doi.org/10.1016/S1040-8428(03)00017-9pl_PL
dc.referencesManning JT (2002) A pointer to fertility, behavior, and health. In: Manning JT (ed) Digit ratio. Rutgers University Press, New Brunswickpl_PL
dc.referencesManning JT (2008) The Finger Ratio. Faber and Faber, Londonpl_PL
dc.referencesManning JT (2011) Resolving the role of prenatal sex steroids in the development of digit ratio. Proc Natl Acad Sci USA 108(39):16143–16144. https://doi.org/10.1073/pnas.1113312108pl_PL
dc.referencesManning JT, Fink B (2018) Sexual dimorphism in the ontogeny of second (2D) and fourth (4D) digit lengths, and digit ratio (2D:4D). Am J Hum Biol 30(4):1–7. https://doi.org/10.1002/ajhb.23138pl_PL
dc.referencesManning JT, Leinster S (2001) The ratio of 2nd to 4th digit length and age at presentation of breast cancer: a link with prenatal oestrogen? Breast 10:355–357pl_PL
dc.referencesManning JT, Scutt D, Wilson J, Lewis-Jones DI (1998) The ratio of 2nd to 4th digit length: A predictor of sperm numbers and concentrations of testosterone, luteinizing hormone and oestrogen. Hum Reprod 13(11):3000–3004. https://doi.org/10.1093/humrep/13.11.3000pl_PL
dc.referencesMardanshahi O, Khayatzadeh J, Shahidsales S. (2017). The relation between the anthropometric characteristics of fingers and cancer ARTICLE INFO ABSTRACT Article type Article history. Medical Sciences (MUMS) Reviews in Clinical Medicine Rev Clin Med, 4(3): 1–4. Retrieved from http://rcm.mums.ac.irpl_PL
dc.referencesMarkou K, Christoforidou A, Karasmanis I, Tsiropoulos G, Triaridis S, Constantinidis I, Nikolaou A (2013) Laryngeal cancer: epidemiological data from Northern Greece and review of the literature. Hippokratia 17(4):313–318pl_PL
dc.referencesMcCormick CM, Carré JM (2020) Facing off with the phalangeal phenomenon and editorial policies: a commentary on Swift-Gallant, Johnson, Di Rita and Breedlove (2020). Horm Behav 120(January):104710. https://doi.org/10.1016/j.yhbeh.2020.104710pl_PL
dc.referencesMuller DC, Giles GG, Bassett J, Morris HA, Manning JT, Hopper JL, Severi G (2011) Second to fourth digit ratio (2D:4D) and concentrations of circulating sex hormones in adulthood. Reprod Biol Endocrinol 9:1–11. https://doi.org/10.1186/1477-7827-9-57pl_PL
dc.referencesOukessou Y, Chebaatha A, Berrada O, Abada RL, Rouadi S, Roubal M, Karkouri M (2022) Primary carcinoma of the larynx in females: a case series. Ann Med Surg 78:103851. https://doi.org/10.1016/j.amsu.2022.103851pl_PL
dc.referencesRahman AA, Lophatananon A, Stewart-Brown S, Harriss D, Anderson J, Parker T, Easton D, Kote-Jarai Z, Pocock R, Dearnaley D, Guy M, O’Brien L, Wilkinson RA, Hall AL, Sawyer E, Page E, Liu JF, UK Genetic Prostate Cancer Study Collaborators, British Association of Urological Surgeon’s Section of Oncology, Eeles RA, Muir K (2011) Hand pattern indicates prostate cancer risk. Br J Cancer 104(1):175–177. https://doi.org/10.1038/sj.bjc.6605986pl_PL
dc.referencesRudić M, Miličić J, Letinić D (2005) Dermatoglyphs and larynx cancer. Coll Antropol 29(1):179–183pl_PL
dc.referencesSchulz M, Hoffmann K, Weikert C, Nöthlings U, Schulze MB, Boeing H (2008) Identification of a dietary pattern characterized by high-fat food choices associated with increased risk of breast cancer: the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study. Br J Nutr 100(5):942–946. https://doi.org/10.1017/S0007114508966149pl_PL
dc.referencesSheahan P (2014) Management of advanced laryngeal cancer. Rambam Maimonides Med J 5(2):e0015. https://doi.org/10.5041/rmmj.10149pl_PL
dc.referencesSingh I, Yadav SPS, Gupta D (2014) Leukoplakia of larynx: a review update. J Laryngol Voice 4(2):39. https://doi.org/10.4103/2230-9748.157464pl_PL
dc.referencesSung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F (2021) Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin 71(3):209–249. https://doi.org/10.3322/caac.21660pl_PL
dc.referencesSwift-Gallant A, Johnson BA, Di Rita V, Breedlove SM (2020) Through a glass, darkly: Human digit ratios reflect prenatal androgens, imperfectly. Horm Behav. https://doi.org/10.1016/j.yhbeh.2020.104686pl_PL
dc.referencesTevfikDorak M, Karpuzoglu E (2012) Gender differences in cancer susceptibility: an inadequately addressed issue. Front Gene 3:1–11. https://doi.org/10.3389/fgene.2012.00268pl_PL
dc.referencesTuncturk FR, Akalin I, Uzun L, Zenginkinet T (2021) Comparison of miRNA expressions among benign, premalignant and malignant lesions of the larynx: could they be transformation biomarkers? J Otolaryngol Head Neck Surg 50(1):1–9. https://doi.org/10.1186/s40463-021-00497-ypl_PL
dc.referencesVerma A, Schwartz N, Cohen DJ, Patel V, Nageris B, Bachar G, Schwartz Z (2020) Loss of estrogen receptors is associated with increased tumor aggression in laryngeal squamous cell carcinoma. Sci Rep 10(1):1–15. https://doi.org/10.1038/s41598-020-60675-2pl_PL
dc.referencesWan P, Ongkasuwan J, Martinez J, Sandulache V, Deng D, Jiang J, Altman KW (2021) Biomarkers for malignant potential in vocal fold leukoplakia: a state of the art review. Otolaryngol Head Neck Surg 164(4):751–758. https://doi.org/10.1177/0194599820957251pl_PL
dc.referencesWang L, Lu H, Li KK, Bai CY, Ma ZB (2018) Digit ratio (2D:4D) in Chinese women with gastric cancer. Am J Hum Biol 30(3):4–6. https://doi.org/10.1002/ajhb.23109pl_PL
dc.referencesYing Y, Madathil S, Nicolau B (2022) Association between the second- and fourth-digit ratio and oral squamous cell carcinoma. Oral Dis. https://doi.org/10.1111/odi.14270pl_PL
dc.referencesZhao J, Leung JYY, Lin SL, Mary Schooling C (2016) Cigarette smoking and testosterone in men and women: a systematic review and meta-analysis of observational studies. Prev Med 85:1–10. https://doi.org/10.1016/j.ypmed.2015.12.021pl_PL
dc.referencesZheng Z, Cohn MJ (2011) Developmental basis of sexually dimorphic digit ratios. Proc Natl Acad Sci USA 108(39):16289–16294. https://doi.org/10.1073/pnas.1108312108pl_PL
dc.identifier.doi10.1007/s00432-023-04850-8
dc.disciplinenauki biologicznepl_PL


Pliki tej pozycji

Thumbnail
Nazwa:
s00432-023-04850-8.pdf
Rozmiar:
664.1KB
Format:
PDF
Opis:
Digit ratio (2D:4D), laryngeal ...
Oglądaj/Otwórz
Thumbnail
Nazwa:
license_rdf
Rozmiar:
908bajtów
Format:
application/rdf+xml
Oglądaj/Otwórz

Pozycja umieszczona jest w następujących kolekcjach

Pokaż uproszczony rekord

Uznanie autorstwa 4.0 Międzynarodowe
Poza zaznaczonymi wyjątkami, licencja tej pozycji opisana jest jako Uznanie autorstwa 4.0 Międzynarodowe