| dc.contributor.author | Dietrich-Muszalska, Anna | |
| dc.contributor.author | Malinowska, Joanna | |
| dc.contributor.author | Olas, Beata | |
| dc.contributor.author | Głowacki, Rafał | |
| dc.contributor.author | Bald, Edward | |
| dc.contributor.author | Wachowicz, Barbara | |
| dc.contributor.author | Rabe-Jabłońska, Jolanta | |
| dc.date.accessioned | 2015-02-13T13:58:29Z | |
| dc.date.available | 2015-02-13T13:58:29Z | |
| dc.date.issued | 2012 | |
| dc.identifier.issn | 1573-6903 | |
| dc.identifier.uri | http://hdl.handle.net/11089/6695 | |
| dc.description.abstract | The mechanisms of oxidative stress in schizophrenic
patients are not fully understood. In the present
study, we investigated the effect of elevated level of homocysteine
(Hcys) on some parameters of oxidative stress,
namely thiobarbituric acid reactive substances (TBARS), an
index of lipid peroxidation in plasma, the level of carbonyl
groups in plasma proteins, as well as the amount of 3-nitrotyrosine
in plasma proteins isolated from schizophrenic
patients. Patients hospitalised in I and II Psychiatric
Department of Medical University in Lodz, Poland were
interviewed with special questionnaire (treatment, course of
diseases, dyskinesis and other EPS). According to DSM-IV
criteria all patients had diagnosis of paranoid type. They
were treated with antipsychotic drugs (clozapine, risperidone,
olanzapine). Mean time of schizophrenia duration was
about 5 years. High-performance liquid chromatography
was used to analyse the total level of homocysteine in
plasma. Levels of carbonyl groups and 3-nitrotyrosine residues
in plasma proteins were measured by ELISA and a
competition ELISA, respectively. The lipid peroxidation in
plasma was measured by the level of TBARS. Our results
showed that in schizophrenic patients the amount of homocysteine
in plasma was higher in comparison with the control
group. We also observed a statistically increased level of
biomarkers of oxidative/nitrative stress such as carbonyl
groups or 3-nitrotyrosine in plasma proteins from schizophrenic
patients. Moreover, our experiments indicate that the
correlation between the increased amount of homocysteine
and the oxidative stress exists. Considering the data presented
in this study, we suggest that the elevated Hcys in
schizophrenic patients may stimulate the oxidative stress. | pl_PL |
| dc.language.iso | en | pl_PL |
| dc.publisher | Springer | pl_PL |
| dc.relation.ispartofseries | Neurochemical Research;2012/37 | |
| dc.subject | Schizophrenic disorders | pl_PL |
| dc.subject | Oxidative stress | pl_PL |
| dc.subject | Carbonyl group | pl_PL |
| dc.subject | Homocysteine | pl_PL |
| dc.title | The Oxidative Stress May be Induced by the Elevated Homocysteine in Schizophrenic Patients | pl_PL |
| dc.type | Article | pl_PL |
| dc.page.number | 1057–1062 | pl_PL |
| dc.contributor.authorAffiliation | A. Dietrich-Muszalska J. Rabe-Jabłońska Department of Affective and Psychotic Disorders, Medical University of Lodz, Czechoslowacka 8/10, 92-216 Lodz | pl_PL |
| dc.contributor.authorAffiliation | J. Malinowska B. Olas (&) B. Wachowicz Department of General Biochemistry, University of Lodz, Pomorska 141/3, 90-236 Lodz | pl_PL |
| dc.contributor.authorAffiliation | R. Głowacki E. Bald Department of Environmental Chemistry, University of Lodz, Pomorska 163, 90-236 Lodz | pl_PL |
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| dc.identifier.doi | 10.1007/s11064-012-0707-3 | |
