| dc.contributor.author | Forma, Ewa | |
| dc.contributor.author | Brzeziańska, Ewa | |
| dc.contributor.author | Krześlak, Anna | |
| dc.contributor.author | Chwatko, Grażyna | |
| dc.contributor.author | Jóźwiak, Paweł | |
| dc.contributor.author | Szymczyk, Agnieszka | |
| dc.contributor.author | Smolarz, Beata | |
| dc.contributor.author | Romanowicz-Makowska, Hanna | |
| dc.contributor.author | Różański, Waldemar | |
| dc.contributor.author | Bryś, Magdalena | |
| dc.date.accessioned | 2015-02-13T14:56:43Z | |
| dc.date.available | 2015-02-13T14:56:43Z | |
| dc.date.issued | 2013 | |
| dc.identifier.issn | 1573-4978 | |
| dc.identifier.uri | http://hdl.handle.net/11089/6699 | |
| dc.description.abstract | Topoisomerase IIb binding protein 1 (TopBP1)
is involved in cell survival, DNA replication, DNA damage
repair and cell cycle checkpoint control. The biological
function of TopBP1 and its close relation with BRCA1
prompted us to investigate whether alterations in the
TopBP1 gene can influence the risk of breast cancer.
The aim of this study was to examine the association
between five polymorphisms (rs185903567, rs116645643,
rs115160714, rs116195487, and rs112843513) located in
the 30UTR region of the TopBP1 gene and breast cancer
risk as well as allele-specific gene expression. Five hundred
thirty-four breast cancer patients and 556 population controls
were genotyped for these SNPs. Allele-specific Top-
BP1 mRNA and protein expressions were determined by
using real time PCR and western blotting methods,
respectively. Only one SNP (rs115160714) showed an
association with breast cancer. Compared to homozygous
common allele carriers, heterozygous and homozygous for
the T variant had significantly increased risk of breast
cancer (adjusted odds ratio = 3.81, 95 % confidence
interval: 1.63–8.34, p = 0.001). Mean TopBP1 mRNA and
protein expression were higher in the individuals with the
CT or TT genotype. There was a significant association
between the rs115160714 and tumor grade and stage. Most
carriers of minor allele had a high grade (G3) tumors
classified as T2-T4N1M0. Our study raises a possibility
that a genetic variation of TopBP1 may be implicated in
the etiology of breast cancer. | pl_PL |
| dc.language.iso | en | pl_PL |
| dc.publisher | Springer | pl_PL |
| dc.relation.ispartofseries | Molecular Biology Reports;2013/40 | |
| dc.subject | Topoisomerase IIb binding protein 1 | pl_PL |
| dc.subject | Polymorphism | pl_PL |
| dc.subject | Genetic variation | pl_PL |
| dc.subject | Breast cancer | pl_PL |
| dc.title | Association between the c.*229C>T polymorphism of the topoisomerase IIb binding protein 1 (TopBP1) gene and breast cancer | pl_PL |
| dc.type | Article | pl_PL |
| dc.page.number | 3493–3502 | pl_PL |
| dc.contributor.authorAffiliation | E. Forma A. Krześlak P. Jóźwiak A. Szymczyk M. Bryś Department of Cytobiochemistry, University of Łodz, Pomorska 141/143, 90-236 Lodz, Poland | pl_PL |
| dc.contributor.authorAffiliation | E. Brzeziańska Department of Molecular Bases of Medicine, Medical University of Łodz, Pomorska 251, 92-213 Lodz, Poland | pl_PL |
| dc.contributor.authorAffiliation | G. Chwatko Department of Environmental Chemistry, University of Łodz, Pomorska 163, 90-236 Lodz, Poland | pl_PL |
| dc.contributor.authorAffiliation | B. Smolarz H. Romanowicz-Makowska Department of Clinical Pathomorphology, Polish Mother’s Memorial Hospital Research Institute, Łodz, Rzgowska 281/289, 93-338 Lodz, Poland | pl_PL |
| dc.contributor.authorAffiliation | W. Różański 2nd Department of Urology, Medical University of Łodz, Pabianicka 62, 93-513 Lodz, Poland | pl_PL |
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| dc.identifier.doi | 10.1007/s11033-012-2424-z | |
