Wydział Biologii i Ochrony Środowiska | Faculty of Biology and Environmental Protection: Ostatnio dodane
Wyświetlanie pozycji 21-40 z 501
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Udział mikrobioty w nasilaniu zmian pronowotworowych w obrębie ludzkiego endometrium oraz potencjał nowych pochodnych niesterydowych leków przeciwzapalnych w zapobieganiu tym procesom
(2024)Rak trzonu macicy stanowi jeden z najczęstszych nowotworów złośliwych żeńskiego układu rozrodczego, a molekularne podstawy rozwoju choroby wciąż pozostają niewyjaśnione. Uznanym czynnikiem sprzyjającym rozwojowi raka ... -
MK-8776 and Olaparib Combination Acts Synergistically in Hepatocellular Carcinoma Cells, Demonstrating Lack of Adverse Effects on Liver Tissues in Ovarian Cancer PDX Model
; ; Marczak, Agnieszka
; ; ; ; ; Bryś, Magdalena ; (MDPI, 2025)
Hepatocellular carcinoma (HCC) cells critically depend on PARP1 and CHK1 activation for survival. Combining the PARP inhibitor (PARPi) olaparib with a CHK1 inhibitor (MK-8776, CHK1i) produced a synergistic effect, reducing ... -
Bioinsektycyd Beauveria bassiana jako mikrobiologiczny czynnik eliminujący mykotoksyny fuzaryjne - MINIATURA 7 (2023/07/X/NZ9/00547)
(2024)During the implementation of the scientific project activity, the growth and sporulation of the entomopathogenic fungus Beauveria bassiana ASREF 2860 were assessed in the presence of Fusarium mycotoxins. Additionally, the ... -
Role of the PARP1/HPF1 complex in the conferring of resistance to doxorubicin in triple negative breast cancer (dataset)
(2023-02-15)Multidrug resistance (MDR) is characterized, inter alia, by overexpression of ABC transporters responsible for the removal of drugs outside the cell and their sequestration in intracellular organelles. Considering that ... -
Pochodne pirazolin skondensowane z chromanonem lub flawanonem w terapii raka jelita grubego: analiza molekularnych aktywności przeciwnowotworowych. - Miniatura 7 2023/07/X/NZ3/01404 (dataset)
(2024)This study investigated the anticancer potential of six flavanone/chromanone derivatives on five human colorectal cancer cell lines (HCT 116, SW620, LoVo, Caco-2, HT-29). Cytotoxicity assays (MTT) revealed that three ... -
Effect of light conditions, Trichoderma fungi and food polymers on growth and profile of biologically active compounds in Thymus vulgaris and Thymus serpyllum (dataset)
(2024-04-29)The research investigates the influence of different lighting conditions and soil treatments, in particular the application of food polymers separately and in combination with spores of Trichoderma consortium, on the ... -
Nanocząstki polistyrenowe i ich właściwości epigenetyczne i genotoksyczne w ludzkich jednojądrzastych komórkach krwi obwodowej - PRELUDIUM-20 nr 2021/41/N/NZ7/02049 (dataset)
(2024)Celem kolejnej części projektu było określenie wpływu krótkotrwałej ekspozycji niefunkcjonalizowanych nanocząstek polistyrenowych (PS-NP) o różnych średnicach 29, 44 i 72 nm na metylację DNA i ekspresję genów w jednojądrzastych ... -
Impact of Short-Term Exposure to Non-Functionalized Polystyrene Nanoparticles on DNA Methylation and Gene Expression in Human Peripheral Blood Mononuclear Cells
(MDPI, 2024-11-28)The aim of the present study was to investigate the concentration- and size-dependent effects of non-functionalized polystyrene nanoparticles (PS-NPs) of varying diameters (29 nm, 44 nm, and 72 nm) on specific epigenetic ... -
Unveiling a Novel Zearalenone Biodegradation Pathway in Metarhizium anisopliae and Elucidating the Role of Cytochrome P450 (dataset)
(2023-01-25)Metarhizium fungi, essential for ecosystem function and commonly utilised in pest control, often occupy ecological niches contaminated by toxic compounds of both anthropogenic and microbi-ological origin. The present study ... -
Szczepy Bacillus i Pseudomonas zdolne do produkcji biosurfaktantów – charakterystyka mechanizmów aktywności przeciwgrzybowej i ocena potencjału aplikacyjnego w obecności wybranych zanieczyszczeń antropogennych
(Uniwersytet Łódzki, 2024)The study investigates the antifungal activity of Bacillus and Pseudomonas strains capable of biosurfactant production, particularly in the presence of anthropogenic pollutants (synthetic pesticides, microplastics, and azo ... -
Does a lower dosage of sewage sludge affect the microbiome and resistome of agricultural soils?
(2025-03)Amendment of soils with sewage sludge are a common practice in agriculture to improve crop yields. Sewage sludge could carry hazardous elements, including prokaryotes that are resistant to antibiotics and heavy metals. ... -
Olaparib Combined with DDR Inhibitors Effectively Prevents EMT and Affects miRNA Regulation in TP53-Mutated Epithelial Ovarian Cancer Cell Lines
(2025)Epithelial ovarian cancer (EOC) remains a leading cause of gynecologic cancer mortality. Despite advances in treatment, metastatic progression and resistance to standard therapies significantly worsen patient outcomes. ... -
Data_Sewage sludge fertilization affects microbial community structure and its resistome in agricultural soils (dataset)
(2025-01-01)Global sewage sludge production is rapidly increasing, and its safe disposal is becoming an increasingly serious issue. One of the main methods of municipal sewage sludge management is based on its agricultural use. The ... -
Data: Impact of aged turkey manure on soil‒plant health: uncovering shifts in microbial diversity and antibiotic resistance genes (dataset)
(2025)This study examines how aged turkey manure affects soil physicochemical properties, microbial diversity, and the distribution of antibiotic resistance genes (ARGs) in the soil‒plant system. The soil properties changed ... -
Data: Game changer? Benomyl as a modulator of paracetamol bioaccumulation and endophytic microbiome diversity in zucchini (dataset)
(2025)Background: Paracetamol, a widely used analgesic and antipyretic, has emerged as a prevalent environmental pollutant that poses risks to various organisms, including plants. Phytoremediation, particularly the use of ... -
Videos for Kok et al 2024 Lost in space and time (dataset)
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Lost in space and time: robust demography and enhanced resilience buffer adverse environmental effects in a highly isolated and sedentary pre-pleistocene landscape vertebrate
(2024-10-11)Background Few animal populations have been studied under the framework of the OCBIL theory, which addresses the ecology and evolution of biodiversity on old climatically buffered infertile landscapes. Available genetic ... -
Induction of expression of genes responsible for biodegradation of MCPA by selected plant secondary metabollites (dataset)
(2025)The main aim of this PRELUDIUM 20 project was to assess the impact of selected PSMs, i.e. syringic acid, caffeic acid, vanillic acid and salicylic acid on: (1) the expression of functional genes responsible for the initial ... -
Molecular mechanisms restoring olaparib efficacy through ATR/CHK1 pathway inhibition in olaparib-resistant BRCA1/2MUT ovarian cancer models (dataset)
(2024)Resistance to olaparib inevitably develops in ovarian cancer (OC) patients, highlighting the necessity for effective strategies to improve its efficacy. Here, we established a novel olaparib-resistant patient-derived ...