Peroksydacja lipidów płytek krwi świni stymulowana działaniem cis- i transplatyn

Abstract

The effects of cisplatin (cisdiamminedichloroplatinum II) at the concentration of 20 µM and transplatin (transdiamminedichloroplatinum II) at the concentrations of 20 µM and 200 and transplatin at the concentration of 200 µM were found to cause a significant increase of thiobarbituric add reactive substances (TBARS). We have demonstrated, that cisplatin - induced platelet lipid peroxidation was enhanced by hypertermia and the presence of plasma had no protective effect on dsplatin or transplatin - stimulated TBARS generation in pig blood platelets. The extracellular GSH (1 mM) protects against dsplatin - induced lipid peroxidation in blood platelets measured as TBARS.