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DNA methylation: gene expression regulation

dc.contributor.authorZmarzły, Nikolaen
dc.contributor.authorWojdas, Emiliaen
dc.contributor.authorSkubis, Aleksandraen
dc.contributor.authorSikora, Bartoszen
dc.contributor.authorMazurek, Urszulaen
dc.date.accessioned2017-03-07T07:40:15Z
dc.date.available2017-03-07T07:40:15Z
dc.date.issued2017-02-07en
dc.identifier.issn1730-2366en
dc.identifier.urihttp://hdl.handle.net/11089/20771
dc.description.abstractEpigenetic modifications are responsible for the modulation of gene expression without affecting the nucleotide sequence. The observed changes in transcriptional activity of genes in tumor tissue compared to normal tissue, are often the result of DNA methylation within the promoter sequences of these genes. This modification by attaching methyl groups to cytosines within CpG islands results in silencing of transcriptional activity of the gene, which in the case of tumor suppressor genes is manifested by abnormal cell cycle, proliferation and excessive destabilization of the repair processes. Further studies of epigenetic modifications will allow a better understanding of mechanisms of their action, including the interdependence between DNA methylation and activity of proteins crucial to the structure of chromatin and gene activity. Wider knowledge of epigenetic mechanisms involved in the process of malignant transformation and pharmacological regulation of the degree of DNA methylation provides an opportunity to improve the therapeutic actions in the fight against cancer.en
dc.publisherWydawnictwo Uniwersytetu Łódzkiegoen
dc.relation.ispartofseriesFolia Biologica et Oecologica;12en
dc.rightsThis work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.en
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0en
dc.subjecttranscriptional activityen
dc.subjectepigeneticsen
dc.subjectcarcinogenesisen
dc.titleDNA methylation: gene expression regulationen
dc.page.number1-10en
dc.contributor.authorAffiliationZmarzły, Nikola - Department of Molecular Biology, School of Pharmacy with the Division of Laboratory Medicine, Medical University of Silesia in Katowice, Jedności 8, 41-200 Sosnowiec, Polanden
dc.contributor.authorAffiliationWojdas, Emilia - Department of Molecular Biology, School of Pharmacy with the Division of Laboratory Medicine, Medical University of Silesia in Katowice, Jedności 8, 41-200 Sosnowiec, Polanden
dc.contributor.authorAffiliationSkubis, Aleksandra - Department of Molecular Biology, School of Pharmacy with the Division of Laboratory Medicine, Medical University of Silesia in Katowice, Jedności 8, 41-200 Sosnowiec, Polanden
dc.contributor.authorAffiliationSikora, Bartosz - Department of Molecular Biology, School of Pharmacy with the Division of Laboratory Medicine, Medical University of Silesia in Katowice, Jedności 8, 41-200 Sosnowiec, Polanden
dc.contributor.authorAffiliationMazurek, Urszula - Department of Molecular Biology, School of Pharmacy with the Division of Laboratory Medicine, Medical University of Silesia in Katowice, Jedności 8, 41-200 Sosnowiec, Polanden
dc.referencesAuerkari, E.I. 2006. Methylation of tumor suppressor genes p16(INK4a), p27(Kip1) and E-cadherin in carcinogenesis. Oral Oncology, 42(1): 5–13.en
dc.referencesBrait, M. & Sidransky, D. 2011. Cancer epigenetics: above and beyond. Toxicology Mechanisms and Methods, 21(4): 275–288. doi: 10.3109/15376516.2011.562671en
dc.referencesCarone, B.R., Fauquier, L., Habib, N., Shea, J.M., Hart, C.E., Li, R., Bock, C., Li, C., Gu, H., Zamore, P.D., Meissner, A., Weng, Z., Hofmann, H.A., Friedman, N. & Rando, O.J. 2010. Paternally induced transgenerational environmental reprogramming of metabolic gene expression in mammals. Cell, 143(7): 1084–1096. ThomsonISI: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000285625400007&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f3en
dc.referencesCheng, J.C., Matsen, C.B., Gonzales, F.A., Ye, W., Greer, S., Marquez, V.E., Jones, P.A. & Selker, E.U. 2003. Inhibition of DNA methylation and reactivation of silenced genes by zebularine. Journal of the National Cancer Institute, 95(5): 399–409.en
dc.referencesChoi, C.H., Lee, K.M., Choi, J.J., Kim, T.J., Kim, W.Y., Lee, J.W., Lee, S.J., Lee, J.H., Bae, D.S. & Kim, B.G. 2007. Hypermethylation and loss of heterozygosity of tumor suppressor genes on chromosome 3p in cervical cancer. Cancer Letters, 255(1): 26–33. ThomsonISI: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000249488700003&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f3en
dc.referencesDaniel, G., Martin, M., Markus, M., Stylianos, M., Mirko, W., Susanne, K., Tobias, B., Martin, B. & Thomas C. 2010. Tissue Distribution of 5-Hydroxymethylcytosine and Search for Active Demethylation Intermediates. PLOS One, 5(12): e15367. doi: 10.1371/journal.pone.0015367 ThomsonISI: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000285579200021&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f3en
dc.referencesDeaton, A.M. & Bird, A. 2011. CpG islands and the regulation of transcription. Genes & Development, 25(10): 1010–1022.en
dc.referencesEhrlich, M. 2009. DNA hypomethylation in cancer cells. Epigenomics, 1(2): 239–259. doi: 10.2217/epi.09.33 ThomsonISI: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000278298900008&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f3en
dc.referencesEsteller, M. 2008. Epigenetics in cancer. The New England Journal of Medicine, 358(11): 1148–1159.en
dc.referencesEsteller, M., Corn, P.G., Baylin, S.B. & Herman, J.G. 2001. A gene hypermethylation profile of human cancer. Cancer Research, 61(8): 3225–3229.en
dc.referencesFicz, G. & Gribben, J.G. 2014. Loss of 5-hydroxymethylcytosine in cancer: cause or consequence? Genomics, 104(5): 352–357. doi: 10.1016/j.ygeno.2014.08.017 ThomsonISI: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000345229600007&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f3en
dc.referencesFlis, S., Flis, K. & Spławiński, J. 2007. Modyfikacje epigenetyczne a nowotwory. Nowotwory Journal of Oncology, 57(4): 427–434.en
dc.referencesGoldberg, A.D., Allis, C.D. & Bernstein, E. 2007. Epigenetics: a landscape takes shape. Cell, 128(4): 635–638. ThomsonISI: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000245098600005&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f3en
dc.referencesGreer, E.L., Maures, T.J., Ucar, D., Hauswirth, A.G., Mancini, E., Lim, J.P., Benayoun, B.A., Shi, Y. & Brunet, A. 2011. Transgenerational epigenetic inheritance of longevity in Caenorhabditis elegans. Nature, 479(7373): 365–371. ThomsonISI: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000297059700038&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f3en
dc.referencesGuz, J., Foksiński, M. & Oliński, R. 2010. Mechanizm metylacji i demetylacji DNA — znaczenie w kontroli ekspresji genów. Postępy Biochemii, 56: 7–15.en
dc.referencesHill, P.W., Amouroux, R. & Hajkova, P. 2014. DNA demethylation, Tet proteins and 5-hydroxymethylcytosine in epigenetic reprogramming: an emerging complex story. Genomics, 104: 324–333. doi: 10.1016/j.ygeno.2014.08.012 ThomsonISI: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000345229600003&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f3en
dc.referencesHirasawa, R., Chiba, H., Kaneda, M., Tajima, S., Li, E., Jaenisch, R. & Sasaki, H. 2008. Maternal and zygotic Dnmt1 are necessary and sufficient for the maintenance of DNA methylation imprints during preimplantation development. Genes & Development, 22(12): 1607–1616.en
dc.referencesJulia, A., Mark, W., Konstantin, L., Julian, R. P., Wolf, R. & Jörn, W. 2015. Selective impairment of methylation maintenance is the major cause of DNA methylation reprogramming in the early embryo. Epigenetics & Chromatin, 8: 1. doi: 10.1186/1756-8935-8-1 ThomsonISI: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000349047700001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f3en
dc.referencesJurkowski, T.P., Ravichandran, M. & Stepper, P. 2015. Synthetic epigenetics-towards intelligent control of epigenetic states and cell identity. Clinical Epigenetics, 7(1): 18. doi: 10.1186/s13148-015-0044-x ThomsonISI: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000350260900001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f3en
dc.referencesKhan, R., Schmidt-Mende, J., Karimi, M., Gogvadze, V., Hassan, M., Ekström, T.J., Zhivotovsky, B. & Hellström-Lindberg, E. 2008. Hypomethylation and apoptosis in 5-azacytidine-treated myeloid cells. Experimental Hematology, 36: 149–157. doi: 10.1016/j.exphem.2007.10.002 ThomsonISI: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000252831400005&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f3en
dc.referencesKiefer, J.C. 2007. Epigenetics in development. Developmental Dynamics, 236(4): 1144–1156. ThomsonISI: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000245883700023&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f3en
dc.referencesKresse, S.H., Rydbeck, H., Skårn, M., Namløs, H.M., Barragan-Polania, A.H., Cleton-Jansen, A.M., Serra, M., Liestøl, K., Hogendoorn, P.C., Hovig, E., Myklebost, O. & Meza-Zepeda, L.A. 2012. Integrative analysis reveals relationships of genetic and epigenetic alterations in osteosarcoma. PLOS One, 7(11): e48262. doi: 10.1371/journal.pone.0048262 ThomsonISI: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000311935800042&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f3en
dc.referencesKunwor, R., Su, Y., Santucci-Pereira, J. & Russo, J. 2015. Present status of epigenetic drugs in cancer treatment. Biohelikon: Cancer and Clinical Research, 3: a17.en
dc.referencesLee, J.Y. & Lee, T.H. 2012. Effects of DNA methylation on the structure of nucleosomes. Journal of the American Chemical Society, 134(1): 173–175.en
dc.referencesLi, J., Poi, M.J. & Tsai, M.D. 2011. The Regulatory Mechanisms of Tumor Suppressor P16INK4A and Relevance to Cancer. Biochemistry, 50(25): 5566–5582. doi: 10.1021/bi200642een
dc.referencesLin, C.H., Hsieh, S.Y., Sheen, I.S., Lee, W.C., Chen, T.C., Shyu, W.C. & Liaw, Y.F. 2001. Genome-wide hypomethylation in hepatocellular carcinogenesis. Cancer Research, 61(10): 4238–4243.en
dc.referencesLinhart, H.G., Lin, H., Yamada, Y., Moran, E., Steine, E.J., Gokhale, S., Lo, G., Cantu, E., Ehrich, M., He, T., Meissner, A. & Jaenisch, R. 2007. Dnmt3b promotes tumorigenesis in vivo by gene-specific de novo methylation and transcriptional silencing. Genes & Development, 21(23): 3110–3122.en
dc.referencesLyko, F., Stach, D., Brenner, A., Stilgenbauer, S., Döhner, H., Wirtz, M., Wiessler, M. & Schmitz, O.J. 2004. Quantitative analysis of DNA methylation in chronic lymphocytic leukemia patients. Electrophoresis, 25(10-11): 1530–1535 doi: 10.1002/elps.200305830en
dc.referencesŁukasik, M., Karmalska, J., Szutowski, M.M. & Łukaszkiewicz, J. 2009. Wpływ metylacji DNA na funkcjonowanie genomu. Biuletyn Wydziału Farmaceutycznego Warszawskiego Uniwersytetu Medycznego, 2: 13–18.en
dc.referencesMajchrzak, A. & Baer-Dubowska, W. 2009. Markery epigenetyczne w diagnostyce: Metody oceny metylacji DNA. Diagnostyka laboratoryjna, 45(2): 167–173.en
dc.referencesMarquardt, J.U., Fischer, K., Baus, K., Kashyap, A., Ma, S., Krupp, M., Linke, M., Teufel, A., Zechner, U., Strand, D., Thorgeirsson, S.S., Galle, P.R. & Strand, S. 2013. Sirtuin-6-dependent genetic and epigenetic alterations are associated with poor clinical outcome in hepatocellular carcinoma patients. Hepatology, 58(3): 1054–1064. doi: 10.1002/hep.26413 ThomsonISI: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000329284000026&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f3en
dc.referencesNakamura, K., Nakabayashi, K., Aung, K.H., Aizawa, K., Hori, N., Yamauchi, J., Hata, K. & Tanoue, A. 2015. DNA methyltransferase inhibitor zebularine induces human cholangiocarcinoma cell death through alteration of DNA methylation status. PLOS One, 10(3): e0120545. doi: 10.1371/journal.pone.0120545 ThomsonISI: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000351987300151&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f3en
dc.referencesOgoshi, K., Hashimoto, S., Nakatani, Y., Qu, W., Oshima, K., Tokunaga, K., Sugano, S., Hattori, M., Morishita, S. & Matsushima, K. 2011. Genome-wide profiling of DNA methylation in human cancer cells. Genomics, 98(4): 280–287. doi: 10.1016/j.ygeno.2011.07.003 ThomsonISI: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000295896300007&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f3en
dc.referencesRauch, T.A., Zhong, X., Wu, X., Wang, M., Kernstine, K.H., Wang, Z., Riggs, A.D. & Pfeifer, G.P. 2008. High-resolution mapping of DNA hypermethylation and hypomethylation in lung cancer. Proceedings of the National Academy of Sciences of the United States of America, 105(1): 252–257.en
dc.referencesRiggins, G.J. & Borodovsky, A. 2014. Optimization of demethylating therapy for idh1 mutant gliomas. Neuro-Oncology, 16(3): iii31.en
dc.referencesRobert, I., Alastair, K., Dina, D, Helle, J., Peter, E., Jim, S., David, J., Chris, C., Robert, P., Jane, R., Sean, H., Tony, C., Cordelia, L. & Adrian, B. 2008. A Novel CpG Island Set Identifies Tissue-Specific Methylation at Developmental Gene Loci. PLOS Biology, 6(1): e22. ThomsonISI: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000254928300006&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f3en
dc.referencesRush, L.J., Dai, Z., Smiraglia, D.J., Gao, X., Wright, F.A., Frühwald, M., Costello, J.F., Held, W.A., Yu, L., Krahe, R., Kolitz, J.E., Bloomfield, C.D., Caligiuri, M.A. & Plass, C. 2001. Novel methylation targets in de novo acute myeloid leukemia with prevalence of chromosome 11 loci. Blood, 97(10): 3226–3233.en
dc.referencesSadikovic, B., Al-Romaih, K., Squire, J. & Zielenska, M. 2008. Cause and Consequences of Genetic and Epigenetic Alterations in Human Cancer. Current Genomics, 9(6): 394–408. doi: 10.2174/138920208785699580 ThomsonISI: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000260015900004&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f3en
dc.referencesSaxonov, S., Berg, P. & Brutlag, D.L. 2006. A genome-wide analysis of CpG dinucleotides in the human genome distinguishes two distinct classes of promoters. Proceedings of the National Academy of Sciences of the United States of America, 103(5): 1412–1417.en
dc.referencesSharma, S., Kelly, T.K. & Jones, P.A. 2010. Epigenetics in cancer. Carcinogenesis, 31(1): 27-36. doi: 10.1093/carcin/bgp220 ThomsonISI: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000273493100004&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f3en
dc.referencesStach, D., Schmitz, O.J., Stilgenbauer, S., Benner, A., Döhner, H., Wiessler, M. & Lyko, F. 2003. Capillary electrophoretic analysis of genomic DNA methylation levels. Nucleic Acids Research, 31(2): E2. doi: 10.1093/nar/gng002en
dc.referencesStöcklein, H., Smardova, J., Macak, J., Katzenberger, T., Höller, S., Wessendorf, S., Hutter, G., Dreyling, M., Haralambieva, E., Mäder, U., Müller-Hermelink, H.K., Rosenwald, A., Ott, G. & Kalla, J. 2008. Detailed mapping of chromosome 17p deletions reveals HIC1 as a novel tumor suppressor gene candidate telomeric to TP53 in diffuse large B-cell lymphoma. Oncogene, 27(18): 2613–2625.en
dc.referencesSulewska, A., Niklinska, W., Kozlowski, M., Minarowski, L., Naumnik, W., Niklinski, J., Dabrowska, K. & Chyczewski, L. 2007. DNA methylation in states of cell physiology and pathology. Folia Histochemica et Cytobiologica, 45(3): 149–158.en
dc.referencesTahiliani, M., Koh, K.P., Shen, Y., Pastor, W.A., Bandukwala, H., Brudno, Y., Agarwal, S., Iyer, L.M., Liu, D.R., Aravind, L. & Rao, A. 2009. Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science, 324(5929): 930–935.en
dc.referencesTan, L. & Shi, Y.G. 2012. Tet family proteins and 5-hydroxymethylcytosine in development and disease. Development, 139(11): 1895–1902. ThomsonISI: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000303914300005&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f3en
dc.referencesTsai, H.C. & Baylin, S.B. 2011. Cancer epigenetics: linking basic biology to clinical medicine. Cell Research, 21(3): 502–517. doi: 10.1038/cr.2011.24 ThomsonISI: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000288064900011&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f3en
dc.referencesWilson, A.S., Power, B.E. & Molloy, P.L. 2007. DNA hypomethylation and human diseases. Biochimica et Biophysica Acta, 1775(1): 138–162.en
dc.referencesWu, H. & Zhang, Y. 2011. Mechanisms and functions of Tet protein-mediated 5-methylcytosine oxidation. Genes & Development, 25(23): 2436–2452.en
dc.referencesYang, X., Han, H., De Carvalho, D. D., Lay, F. D., Jones, P. A., & Liang, G. 2014. Gene Body Methylation can alter Gene Expression and is a Therapeutic Target in Cancer. Cancer Cell, 26(4), 577–590. doi: 10.1016/j.ccr.2014.07.028 ThomsonISI: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000343343800016&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f3en
dc.referencesYou, J.S. & Jones, P.A. 2012. Cancer Genetics and Epigenetics: Two Sides of the Same Coin? Cancer Cell, 22(1): 9–20. doi: 10.1016/j.ccr.2012.06.008 ThomsonISI: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000306395300005&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f3en
dc.contributor.authorEmailZmarzły, Nikola - nikola.zmarzly@gmail.comen
dc.identifier.doi10.1515/fobio-2016-0001en


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