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Impaired base excision repair is related to the pathogenesis of non-alcoholic fatty liver disease

dc.contributor.authorZiółkowska, Sylwia
dc.contributor.authorCzarny, Piotr
dc.contributor.authorSzemraj, Janusz
dc.date.accessioned2021-08-27T09:53:19Z
dc.date.available2021-08-27T09:53:19Z
dc.date.issued2020-12-30
dc.identifier.issn1730-2366
dc.identifier.urihttp://hdl.handle.net/11089/38847
dc.description.abstractNon-alcoholic fatty disease (NAFLD) is a liver disorder that affects up to 30% of the population, mainly in Western countries. It is estimated that up to 75% of NAFLD patients will develop a more aggressive form of the disease, non-alcoholic steatohepatitis (NASH). NAFLD can lead to fibrosis and liver failure; however, it is difficult to diagnose NAFLD due to its non-specific symptoms. Unfortunately, there is no treatment available for this disease. The risk factors of NAFLD are obesity and insulin resistance (IR). The molecular factors that seem to play an important role in the pathogenesis of NAFLD are oxidative stress as well as impaired DNA damage repair processes; a great body of evidence confirms an association with the base excision repair (BER) pathway. The activity of BER is decreased in patients with NAFLD and in animal models of this disease. In order to better understand the underlying basis of the disease, knowledge should be broadened in the area of DNA repair in NAFLD.en
dc.language.isoen
dc.publisherWydawnictwo Uniwersytetu Łódzkiegopl
dc.relation.ispartofseriesActa Universitatis Lodziensis. Folia Biologica et Oecologicaen
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0
dc.subjectDNA repairen
dc.subjectnon-alcoholic fatty liveren
dc.subjectbase excision repairen
dc.titleImpaired base excision repair is related to the pathogenesis of non-alcoholic fatty liver diseaseen
dc.typeArticle
dc.page.number5-11
dc.contributor.authorAffiliationZiółkowska, Sylwia - Medical University of Lodz, Department of Medical Biochemistry, Mazowiecka 6/8, 92-215 Lodz, Polanden
dc.contributor.authorAffiliationCzarny, Piotr - Medical University of Lodz, Department of Medical Biochemistry, Mazowiecka 6/8, 92-215 Lodz, Polanden
dc.contributor.authorAffiliationSzemraj, Janusz - Medical University of Lodz, Department of Medical Biochemistry, Mazowiecka 6/8, 92-215 Lodz, Polanden
dc.identifier.eissn2083-8484
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dc.contributor.authorEmailZiółkowska, Sylwia - sylwia.ziolkowska@umed.lodz.pl
dc.contributor.authorEmailCzarny, Piotr - sylwia.ziolkowska@umed.lodz.pl
dc.contributor.authorEmailSzemraj, Janusz - sylwia.ziolkowska@umed.lodz.pl
dc.identifier.doi10.18778/1730-2366.16.01
dc.relation.volume16


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