| dc.contributor.author | Żolnierczyk, Jolanta | en |
| dc.contributor.author | Kiliańska, Zofia | en |
| dc.date.accessioned | 2015-06-17T08:35:22Z | |
| dc.date.available | 2015-06-17T08:35:22Z | |
| dc.date.issued | 2011-03-04 | en |
| dc.identifier.issn | 1730-2366 | |
| dc.identifier.uri | http://hdl.handle.net/11089/9866 | |
| dc.description.abstract | Programmed cell death (apoptosis) plays a vital role in the regulation of cellular homeostasis. Because of apoptosis fundamental importance, this process is highly regulated. One important set of factors involved in apoptosis regulation is the Bcl-2 family proteins. Bcl-2 family members form a complex regulatory network that controls cell survival and death in response to different physiological and pathological signals. This family includes both pro- and anti-apoptotic members, and Bax protein (Mol wt 21 kDa) is a major pro-apoptotic factor with multifunctional activity. This review summarizes new data about the main representative of Bcl-2 family-Bax, its structure and mechanism(s) by which this protein modulates apoptosis. | en |
| dc.publisher | Wydawnictwo Uniwersytetu Łódzkiego | en |
| dc.relation.ispartofseries | Folia Biologica et Oecologica;6 | en |
| dc.rights | This content is open access. | en |
| dc.subject | apoptosis | en |
| dc.subject | Bcl-2 family | en |
| dc.subject | Bax | en |
| dc.subject | apoptosis mitochondrial pathway | en |
| dc.title | Main Pro-Apoptotic Member of BCL-2 Family Proteins-BAX | en |
| dc.page.number | 5-32 | en |
| dc.contributor.authorAffiliation | Żolnierczyk Jolanta - Department of Cytobiochemistry, University of Łódź, Pomorska 141/143, 90-236 Łódź, Poland | en |
| dc.contributor.authorAffiliation | Kiliańska Zofia - Department of Cytobiochemistry, University of Łódź, Pomorska 141/143, 90-236 Łódź, Poland | en |
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| dc.identifier.doi | 10.2478/v10107-009-0004-3 | en |
