Wpływ IFO na aktywność mikrosomalnych i cytozolowych transferaz S-glutationowych (GST) w limfocytach krwi obwodowej świni

Abstract

The effects of organ ophosphorus insecticides (IFO), on the activity of gluthathione S-transferase (GST) of pig lymphocytes were investigated. Activity of microsomal GST with both CDNB and DCNB as substrates was observed, activity of cytosolic GST only with CDNB. After incubation of lymfocytes with IFO (malathion and methylparathion), activity of GST was increased. The observed changes were dependend on the structure of tested compounds, its dose and time incubation.