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Polystyrene nanoparticles: the mechanism of their genotoxicity in human peripheral blood mononuclear cells

dc.contributor.authorMalinowska, Kinga
dc.contributor.authorBukowska, Bożena
dc.contributor.authorPiwoński, Ireneusz
dc.contributor.authorFoksiński, Marek
dc.contributor.authorKisielewska, Aneta
dc.contributor.authorZarakowska, Ewelina
dc.contributor.authorGackowski, Daniel
dc.contributor.authorSicińska, Paulina
dc.date.accessioned2023-11-22T16:24:08Z
dc.date.available2023-11-22T16:24:08Z
dc.date.issued2022
dc.identifier.issn1743-5404
dc.identifier.urihttp://hdl.handle.net/11089/48404
dc.description.abstractPlastic nanoparticles are widely spread in the biosphere, but health risk associated with their effect on the human organism has not yet been assessed. The purpose of this study was to determine the genotoxic potential of non-functionalized polystyrene nanoparticles (PS-NPs) of different diameters of 29, 44, and 72nm in human peripheral blood mononuclear cells (PBMCs) (in vitro). To select non-cytotoxic concentrations of tested PS-NPs, we analyzed metabolic activity of PBMCs incubated with these particles in concentrations ranging from 0.001 to 1000 ug/mL. Then, PS-NPs were used in concentrations from 0.0001 to 100 ug/mL and incubated with tested cells for 24 h. Physico-chemical properties of PS-NPs in media and suspension were analyzed using dynamic light scattering (DLS), atomic force microscopy (AFM), scanning electron microscopy (SEM) and zeta potential. For the first time, we investigated the mechanism of genotoxic action of PS-NPs based on detection of single/double DNA strand-breaks and 8-oxo-2'-deoxyguanosine (8-oxodG) formation, as well as determination of oxidative modification of purines and pyrimidines and repair efficiency of DNA damage. Obtained results have shown that PS-NPs caused a decrease in PBMCs metabolic activity, increased single/double-strand break formation, oxidized purines and pyrimidines and increased 8oxodG levels. The resulting damage was completely repaired in the case of the largest PS-NPs. It was also found that extent of genotoxic changes in PBMCs depended on the size of tested particles and their f-potential value.pl_PL
dc.description.sponsorshipNarodowe Centrum Nauki (NCN), Preludium 20 nr 2021/41/N/NZ7/02049pl_PL
dc.language.isoenpl_PL
dc.publisherTaylor & Francispl_PL
dc.relation.ispartofseriesNanotoxicology;6-8
dc.rightsUznanie autorstwa 4.0 Międzynarodowe*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectpolystyrene nanoparticlespl_PL
dc.subjectperipheral blood mononuclear cellspl_PL
dc.subjectDNA strand-breakspl_PL
dc.subjectoxidation of purinespl_PL
dc.subjectoxidation of pyrimidinespl_PL
dc.subject8-oxo-20-deoxyguanosinepl_PL
dc.titlePolystyrene nanoparticles: the mechanism of their genotoxicity in human peripheral blood mononuclear cellspl_PL
dc.typeArticlepl_PL
dc.page.number791-811pl_PL
dc.contributor.authorAffiliationDepartment of Biophysics of Environmental Pollution, Faculty of Biology and Environmental Protection, University of Lodzpl_PL
dc.contributor.authorAffiliationDepartment of Materials Technology and Chemistry, Faculty of Chemistry, University of Lodzpl_PL
dc.contributor.authorAffiliationDepartment of Clinical Biochemistry, Faculty of Pharmacy, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruńpl_PL
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dc.contributor.authorEmailkinga.malinowska@edu.uni.lodz.plpl_PL
dc.identifier.doi10.1080/17435390.2022.2149360
dc.relation.volume16pl_PL
dc.disciplinenauki biologicznepl_PL


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Uznanie autorstwa 4.0 Międzynarodowe
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