Proces sekrecji płytek krwi wywołany promieniowaniem UVB

Abstract

The effects of two doses of UVB radiation (1.08 J/cm2 and 4.32 J/cm2; 1.2 mW/cm2) on blood platelets secretion of adenine nucleotides and proteins and P selectin expression were studied. The effect of UVB radiation on P selectin expression (marker of platelet activation) was compared with the effect of thrombin, which is a strong platelet agonist. The obtained results showed that exposure of blood platelet to UVB radiation caused the release of adenine nucleotides, but proteins in a small amount. Moreover, UVB radiation caused decrease of P selectin expression on blood platelets, in opposite to the effect of thrombin. It seems that UVB radiation can partly activate blood platelets, but the mechanism is needed to be explain.