RSS 1.0Dane badawcze i projekty | Research data and projects
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Dane badawcze | Research Data [42]
Dane badawcze zebrane w ramach projektów realizowanych na Wydziale Biologii i Ochrony Środowiska | Research data collected as part of projects carried out at the Faculty of Biology and Environmental Protection
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Terpene-Based Eutectic Solvent Microdroplets: A Strategy to Combat Antibiotic-Resistant Helicobacter pylori (dataset)
(2025-05-22)Terpene-based therapeutic eutectic solvents (THEES) represent an innovative class of green solvents with intrinsic antimicrobial properties, offering new potential for sustainable solutions in the treatment of microbial ... -
In vivo upregulation of innate and adaptive immune mechanisms in guinea pigs inoculated with Helicobacter pylori in response to Mycobacterium bovis BCG delivered by chitosan microparticles (dataset)
(2025-12-14)In this study, we used the model of Cavia porcellus (guinea pig) experimentally infected with H. pylori to determine whether per os inoculation of animals with chitosan microparticles containing live M. bovis BCG, which ... -
Mycobacterium bovis BCG reverses deleterious effects of H. pylori components towards gastric barrier cells in vitro (dataset)
(2024-07-22)Mycobacterium bovis (M. bovis) Bacillus Calmette-Guerin (BCG) strain used in immunotherapy of bladder cancer (onco-BCG) due to its acid tolerance can be a candidate for prevention or reversion of deleterious effects towards ... -
Untargeted metabolomic profiling for identifying systemic signatures of helicobacter pylori infection in a guinea pig model (dataset)
(2025-04-15)Infections caused by the Gram-negative bacterium Helicobacter pylori (H. pylori) can lead to gastritis, gastric or duodenal ulcers, and even gastric cancer in humans. Investigating quantitative changes in soluble biomarkers ... -
Complex forming properties of cannabinoid acids in a green solvent and bioassays focused on gastric disease caused by Helicobacter pylori infection (dataset)
(2025-05-28)The main objective of the present study was to determine the protolytic and coordination properties of two bioactive cannabinoid acids (cannabidiolic acid and cannabigerolic acid) in ethyl alcohol-water mixture (50/50, ... -
Modulation of the gastrointestinal immune environment by chitosan microparticles loaded with Mycobacterium bovis BCG in a Cavia porcellus model in vivo, leading to reduced experimental H. pylori gastric colonization (dataset)
(2025)Mycobacterium bovis BCG bacilli potentially may train immune cells against microbial pathogens. The increasing antibiotic resistance of the gastric pathogen Helicobacter pylori (Hp) prompts a search for new therapeutics. ... -
Nanocząstki polistyrenowe i ich właściwości epigenetyczne i genotoksyczne w ludzkich jednojądrzastych komórkach krwi obwodowej - PRELUDIUM-20 nr 2021/41/N/NZ7/02049 (dataset)
(2025)W ostatnim etapie projektu zbadano wpływ niefuncjonalizowanych nanocząstek polistyrenu (PS-NP) o średnicach 29, 44 i 72 nm na integralność plazmidowego DNA oraz ekspresję genów zaangażowanych w architekturę chromatyny w ... -
Wastewater as a Driver of Heavy Metal Pollution in River Catchments – a study of possible scenarios (dataset)
(2024)The aim of the study was to analyze (i) the impact of wastewater treatment plants and industrial plants on the pollution of the Pilica River, (ii) heavy metal loads along its continuum, and (iii) the typical pollutant ... -
An analysis of catchment factors associated with heavy metal export into the Baltic Sea and Nature-Based Solutions aimed at its limitation (dataset)
(2024)The aim of the study was to determine the contribution of individual Baltic countries to the inflow of metal loads into the Baltic Sea and to identify patterns of similarity between these countries in terms of the causes ... -
Bioactive Coating with Clindamycin, VEGF-165, and TGF-β1 for Supporting Bone Tissue Regeneration (dataset)
Szwed-Georgiou, Aleksandra
; Włodarczyk, Marcin ; Krupa, Agnieszka ; Rudnicka, Karolina (2025)
The growing demand for implantable devices, implants, and plastic surgery is a major factor driving the growth of the global biomaterials market. Both new materials and opportunities to enhance the properties of existing ... -
Functionalized DOPE/TAP Liposomes Bearing Arginine-Rich Peptides for Efficient siRNA Delivery into Triple-Negative Breast Cancer Cells. Biophysical Characterisation of the Complexes
(2025-06-17)Innovative drug delivery platforms are redefining the landscape of modern therapeutics, from dendrimers and liposomes to polymeric systems and metallic nanoparticles. The development of carrier systems that combine safety, ... -
Bioinsektycyd Beauveria bassiana jako mikrobiologiczny czynnik eliminujący mykotoksyny fuzaryjne - MINIATURA 7 (2023/07/X/NZ9/00547)
(2024)During the implementation of the scientific project activity, the growth and sporulation of the entomopathogenic fungus Beauveria bassiana ASREF 2860 were assessed in the presence of Fusarium mycotoxins. Additionally, the ... -
Role of the PARP1/HPF1 complex in the conferring of resistance to doxorubicin in triple negative breast cancer (dataset)
(2023-02-15)Multidrug resistance (MDR) is characterized, inter alia, by overexpression of ABC transporters responsible for the removal of drugs outside the cell and their sequestration in intracellular organelles. Considering that ... -
Pochodne pirazolin skondensowane z chromanonem lub flawanonem w terapii raka jelita grubego: analiza molekularnych aktywności przeciwnowotworowych. - Miniatura 7 2023/07/X/NZ3/01404 (dataset)
(2024)This study investigated the anticancer potential of six flavanone/chromanone derivatives on five human colorectal cancer cell lines (HCT 116, SW620, LoVo, Caco-2, HT-29). Cytotoxicity assays (MTT) revealed that three ... -
Effect of light conditions, Trichoderma fungi and food polymers on growth and profile of biologically active compounds in Thymus vulgaris and Thymus serpyllum (dataset)
(2024-04-29)The research investigates the influence of different lighting conditions and soil treatments, in particular the application of food polymers separately and in combination with spores of Trichoderma consortium, on the ... -
Nanocząstki polistyrenowe i ich właściwości epigenetyczne i genotoksyczne w ludzkich jednojądrzastych komórkach krwi obwodowej - PRELUDIUM-20 nr 2021/41/N/NZ7/02049 (dataset)
(2024)Celem kolejnej części projektu było określenie wpływu krótkotrwałej ekspozycji niefunkcjonalizowanych nanocząstek polistyrenowych (PS-NP) o różnych średnicach 29, 44 i 72 nm na metylację DNA i ekspresję genów w jednojądrzastych ... -
Unveiling a Novel Zearalenone Biodegradation Pathway in Metarhizium anisopliae and Elucidating the Role of Cytochrome P450 (dataset)
(2023-01-25)Metarhizium fungi, essential for ecosystem function and commonly utilised in pest control, often occupy ecological niches contaminated by toxic compounds of both anthropogenic and microbi-ological origin. The present study ... -
Does a lower dosage of sewage sludge affect the microbiome and resistome of agricultural soils?
(2025-03)Amendment of soils with sewage sludge are a common practice in agriculture to improve crop yields. Sewage sludge could carry hazardous elements, including prokaryotes that are resistant to antibiotics and heavy metals. ... -
Olaparib Combined with DDR Inhibitors Effectively Prevents EMT and Affects miRNA Regulation in TP53-Mutated Epithelial Ovarian Cancer Cell Lines
(2025)Epithelial ovarian cancer (EOC) remains a leading cause of gynecologic cancer mortality. Despite advances in treatment, metastatic progression and resistance to standard therapies significantly worsen patient outcomes. ... -
Data_Sewage sludge fertilization affects microbial community structure and its resistome in agricultural soils (dataset)
(2025-01-01)Global sewage sludge production is rapidly increasing, and its safe disposal is becoming an increasingly serious issue. One of the main methods of municipal sewage sludge management is based on its agricultural use. The ...