Krzepnięcie krwi i fibrynoliza w zatruciu etanolem i acetaldehydem

Abstract

Rats intoxicated with ethanol and acetaldehyde during 2 months showed increase of the thromboplastic activity in the kidney homogenate and decrease of this activity in the lung homogenate. Besides the intoxication with acetaldehyde increased activity of plasminogen in the homogenate of these organs. Antiplasmin activity decreased in the kidney and lung homogenates after one months and in the stomach homogenate after two months of intoxication with ethanol and acetaldehyde. The time of recalcination and the prothrombin time were slightly shorter in the plasma of rats intoxicated with ethanol and acetaldehyde and the fibrinogen level was increased. The time of the euglobulin fibrinolysis is slightly prolonged after the two months intoxication. The plasminogen level was simultaneously slightly increased. The antiplasmin activity was slightly decreased after one month of the intoxication with ethanol and acetaldehyde but in the second month of the intoxication the activity of this inhibitor was slightly -increased.